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Nature 428, 32-33 (4 March 2004) | doi:10.1038/428032b
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- Rhydburg Pharmaceuticals
- Selaqui-Dehradun India
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- University of Cincinnati and Cincinnati Children's Research Foundation
- Cincinnati, OH
Cell division: Feeling tense enough?
Iain M. Cheeseman1 & Arshad Desai1
Abstract
Accurately distributing half of each replicated chromosome to both daughters is a major challenge for dividing cells. The mechanisms used to achieve this are becoming apparent, thanks to studies old and new.
At the beginning of mitosis, the process of cell division, chromosomes are organized randomly — like jigsaw puzzle pieces spread out on the floor. Their constituent two 'sister chromatids', each of which contains one of the two identical DNA molecules produced by replication, must be oriented such that they will be pulled in opposite directions into the two newly forming cells.
- Iain M. Cheeseman and Arshad Desai are at the Ludwig Institute for Cancer Research and the University of California, San Diego, La Jolla, California 92093, USA.
e-mails: Email: icheeseman@ucsd.edu
Email: abdesai@ucsd.edu
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