Common wisdom holds that ion channels and ion pumps, with their obvious functional differences, should have visibly dissimilar structures. It seems that's not necessarily so.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Accardi, A. & Miller, C. Nature 427, 803–807 (2004).
Maduke, M., Pheasant, D. J. & Miller, C. J. Gen. Physiol. 114, 713–722 (1999).
Dutzler, R., Campbell, E. B., Cadene, M., Chait, B. T. & MacKinnon, R. Nature 415, 287–294 (2002).
Iyer, R., Iverson, T. M., Accardi, A. & Miller, C. Nature 419, 715–718 (2002).
Dutzler, R., Campbell, E. B. & MacKinnon, R. Science 300, 108–112 (2003).
Zhou Y., Morais-Cabral, J. H., Kaufman, A. & MacKinnon, R. Nature 414, 43–48 (2001).
Accardi, A., Kolmakova-Partensky, L., Williams, C. & Miller, C. J. Gen. Physiol. 123, 109–119 (2004).
Toyoshima, C. & Nomura, H. Nature 418, 605–611 (2002).
Unwin, N., Miyazawa, A., Li, J. & Fujiyoshi, Y. J. Mol. Biol. 319, 1165–1176 (2002).
Jiang, Y. et al. Nature 417, 515–522 (2002).
Jiang, Y., Ruta, V., Chen, J., Lee, A. & MacKinnon, R. Nature 423, 42–48 (2003).
Chen, M. F. & Chen, T. Y. J. Gen. Physiol. 118, 23–32 (2001).
Lin, C. W. & Chen, T. Y. J. Gen. Physiol. 122, 147–159 (2003).
Miller, C. Phil. Trans. R. Soc. Lond. B 299, 401–411 (1982).
Estévez, R., Schroeder, B. C., Accardi, A., Jentsch, T. J. & Pusch, M. Neuron 38, 47–59 (2003).
Chen, M. F. & Chen, T. Y. J. Gen. Physiol. 122, 133–145 (2003).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Gadsby, D. Spot the difference. Nature 427, 795–797 (2004). https://doi.org/10.1038/427795a
Issue Date:
DOI: https://doi.org/10.1038/427795a
This article is cited by
-
Conversion of the 2 Cl−/1 H+ antiporter ClC-5 in a NO3−/H+ antiporter by a single point mutation
The EMBO Journal (2009)
-
Ion channels versus ion pumps: the principal difference, in principle
Nature Reviews Molecular Cell Biology (2009)