Table of contents
Volume 427 Number 6977 pp763-870
Editorial
Time for Japan to shine? p763
Talks last weekend on choosing a site for ITER, the fusion project, ended in stalemate. But ITER deserves to proceed, and Japan's commitment to it is strongest.
doi:10.1038/427763a
News
Media attack prompts editorial backlash against MMR study p765
Jim Giles
doi:10.1038/427765a
Poor communication blamed for delays to US visas p766
Geoff Brumfiel
doi:10.1038/427766a
Mad cow's standing puts downer on testing strategy p766
Erika Check
doi:10.1038/427766b
Labs urged to pre-empt bioterrorism threat p767
Erika Check
doi:10.1038/427767a
Electron movements pinned down to the split second p767
Mark Peplow
doi:10.1038/427767b
Treaty calls time on long-term pollutants p768
Jim Giles
doi:10.1038/427768a
Closure threat propels astronomers to institute's aid p768
Quirin Schiermeier
doi:10.1038/427768b
Gulf Stream probed for early warnings of system failure p769
Quirin Schiermeier
doi:10.1038/427769a
Bioprospectors edge towards deal with developing countries p769
Rex Dalton
doi:10.1038/427769b
News Features
Opinion polling: Taking the voters' pulse p772
Political strategies and careers are built and broken on the results of opinion polls. But polls' apparently small margins of error can hide large uncertainties. Tony Reichhardt surveys the issues.
Disease control: Virtual plagues get real p774
Mathematical models incorporating ecological data are starting to be deployed on the front line in the battle against infectious disease. Virginia Gewin talks to the number-crunchers who are spearheading the assault.
doi:10.1038/427774a
Correspondence
Intelligent plagiarists are the most dangerous p777
How should we tackle the increasing problem of researchers rewriting others' results?
Lennart Stenflo
Overseas scientists still welcome in United States p777
Warren M. Washington
HIV denialists will exploit any journal's tolerance p777
John P. Moore
Commentary
The future of gene therapy p779
Balancing the risks and benefits of clinical trial.
doi:10.1038/427779a
Books and Arts
From spears to speech p783
Could throwing spears have laid the foundations for language acquisition?
Robin Dunbar reviews A Brief History of the Mind: From Apes to Intellect and Beyond by William H. Calvin
Trying to beat the clock p784
Till Roenneberg reviews Rhythms of Life: The Biological Clocks that Control the Daily Lives of Every Living Thing by Russell Foster and Leon Kreitzman
New in paperback p784
Science in culture p785
The first images from the Mars Express orbiter highlight the universal beauty of the wilderness.
Martin Kemp reviews
Essay
ConceptCancer without disease p787
Do inhibitors of blood-vessel growth found naturally in our bodies defend most of us against progression of cancer to a lethal stage?
Judah Folkman and Raghu Kalluri
News and Views
Turning the key on p53 p789
The p53 protein is among the most effective of the body's natural defences against cancer. News comes of a promising way of releasing the protein from its inhibitions to carry out its anti-tumour duties.
David P. Lane and Peter M. Fischer
Astronomy: Out of the Dark Ages p790
Light from the most distant sources known, emitted when the Universe was only a billion years old, hints at a complex history of star and galaxy formation, and at their effect on the primordial gas around them.
S. George Djorgovski
HIV: Replication trimmed back p791
A long-standing point of intrigue has been how certain non-human primates are resistant to HIV-1. The discovery in macaque monkeys of a protein that resides in mysterious cytoplasmic bodies holds the key.
Stephen P. Goff
Earth science: Through thick and thin p793
The sea floor around the Hawaiian island chain is unusually shallow. New seismic evidence suggests that this up-raised 'swell' is partly due to heating and thinning of the lithosphere beneath.
Neil M. Ribe
Ion transport: Spot the difference p795
Common wisdom holds that ion channels and ion pumps, with their obvious functional differences, should have visibly dissimilar structures. It seems that's not necessarily so.
David C. Gadsby
100 and 50 years ago p795
Neurobiology: A move to sort life from death p798
Nerve growth factor determines neuronal cell fate during development or after injury. A newly identified 'death factor', an unprocessed form of this protein, induces cell death by activating two receptors in concert.
David R. Kaplan and Freda D. Miller
Superconductivity: Symmetry not required p799
Superconductivity is a complex phenomenon. And now there's something else to think about: a magnetic material whose structure is not mirror symmetric and yet, unexpectedly, superconducts.
S. S. Saxena and P. Monthoux
News and views in brief p800
Brief Communications
Glutamate receptors: RNA editing and death of motor neurons p801
There is a glutamate-receptor defect in patients with amyotrophic lateral sclerosis.
Yukio Kawahara, Kyoko Ito, Hui Sun, Hitoshi Aizawa, Ichiro Kanazawa and Shin Kwak
First paragraph | Full Text | PDF (86K) | Supplementary information
Electron-spin domains (communication arising): Magnetic enhancement of superconductivity p802
Roman Movshovich, Andrea Bianchi, Cigdem Capan, Marcelo Jaime and R.G. Goodrich
First paragraph | Full Text | PDF (75K)
Electron-spin domains (communication arising): Magnetic enhancement of superconductivity p802
H. A. Radovan, N. A. Fortune, T. P. Murphy, S. T. Hannahs, E. C. Palm, S. W. Tozer and D. Hall
First paragraph | Full Text | PDF (75K)
Articles
Secondary active transport mediated by a prokaryotic homologue of ClC Cl- channels p803
Alessio Accardi and Christopher Miller
doi:10.1038/nature02314
Abstract | Full Text | PDF (373K)
Structure of the signal recognition particle interacting with the elongation-arrested ribosome p808
Mario Halic, Thomas Becker, Martin R. Pool, Christian M. T. Spahn, Robert A. Grassucci, Joachim Frank and Roland Beckmann
doi:10.1038/nature02342
Abstract | Full Text | PDF (491K) | Supplementary information
Letters to Nature
A large neutral fraction of cosmic hydrogen a billion years after the Big Bang p815
J. Stuart B. Wyithe and Abraham Loeb
doi:10.1038/nature02336
First paragraph | Full Text | PDF (149K)
See also: News and Views by Djorgovski
Atomic transient recorder p817
R. Kienberger, E. Goulielmakis, M. Uiberacker, A. Baltuska, V. Yakovlev, F. Bammer, A. Scrinzi, Th. Westerwalbesloh, U. Kleineberg, U. Heinzmann, M. Drescher and F. Krausz
doi:10.1038/nature02277
First paragraph | Full Text | PDF (1,061K)
Giant magnetoresistance in organic spin-valves p821
Z. H. Xiong, Di Wu, Z. Valy Vardeny and Jing Shi
doi:10.1038/nature02325
First paragraph | Full Text | PDF (360K) | Supplementary information
Bottom water warming in the North Pacific Ocean p825
Masao Fukasawa, Howard Freeland, Ron Perkin, Tomowo Watanabe, Hiroshi Uchida and Ayako Nishina
doi:10.1038/nature02337
First paragraph | Full Text | PDF (347K)
Rejuvenation of the lithosphere by the Hawaiian plume p827
Xueqing Li, Rainer Kind, Xiaohui Yuan, Ingo Wölbern and Winfried Hanka
doi:10.1038/nature02349
First paragraph | Full Text | PDF (210K) | Supplementary information
See also: News and Views by Ribe
Iron corrosion by novel anaerobic microorganisms p829
Hang T. Dinh,
Jan Kuever,
Marc Mu
mann,
Achim W. Hassel,
Martin Stratmann
and
Friedrich Widdel
doi:10.1038/nature02321
First paragraph | Full Text | PDF (291K) | Supplementary information
Conventional taxonomy obscures deep divergence between Pacific and Atlantic corals p832
Hironobu Fukami, Ann F. Budd, Gustav Paulay, Antonio Solé-Cava, Chaolun Allen Chen, Kenji Iwao and Nancy Knowlton
doi:10.1038/nature02339
First paragraph | Full Text | PDF (750K) | Supplementary information
Phylogenetic constraints and adaptation explain food-web structure p835
Marie-France Cattin,
Louis-Félix Bersier,
Carolin Bana
ek-Richter,
Richard Baltensperger
and
Jean-Pierre Gabriel
doi:10.1038/nature02327
First paragraph | Full Text | PDF (379K)
Global organization of metabolic fluxes in the bacterium Escherichia coli p839
E. Almaas, B. Kovács, T. Vicsek, Z. N. Oltvai and A.-L. Barabási
doi:10.1038/nature02289
First paragraph | Full Text | PDF (463K) | Supplementary information
Sortilin is essential for proNGF-induced neuronal cell death p843
Anders Nykjaer, Ramee Lee, Kenneth K. Teng, Pernille Jansen, Peder Madsen, Morten S. Nielsen, Christian Jacobsen, Marco Kliemannel, Elisabeth Schwarz, Thomas E. Willnow, Barbara L. Hempstead and Claus M. Petersen
doi:10.1038/nature02319
First paragraph | Full Text | PDF (640K)
See also: News and Views by Kaplan & Miller
The cytoplasmic body component TRIM5
restricts HIV-1 infection in Old World monkeys p848
Matthew Stremlau, Christopher M. Owens, Michel J. Perron, Michael Kiessling, Patrick Autissier and Joseph Sodroski
doi:10.1038/nature02343
First paragraph | Full Text | PDF (539K) | Supplementary information
See also: News and Views by Goff
The large-conductance Ca2+-activated K+ channel is essential for innate immunity p853
Jatinder Ahluwalia, Andrew Tinker, Lucie H. Clapp, Michael R. Duchen, Andrey Y. Abramov, Simon Pope, Muriel Nobles and Anthony W. Segal
doi:10.1038/nature02356
First paragraph | Full Text | PDF (2,234K)
OXI1 kinase is necessary for oxidative burst-mediated signalling in Arabidopsis p858
Maike C. Rentel, David Lecourieux, Fatma Ouaked, Sarah L. Usher, Lindsay Petersen, Haruko Okamoto, Heather Knight, Scott C. Peck, Claire S. Grierson, Heribert Hirt and Marc R. Knight
doi:10.1038/nature02353
First paragraph | Full Text | PDF (311K) | Supplementary information
Visualization of release factor 3 on the ribosome during termination of protein synthesis p862
Bruno P. Klaholz, Alexander G. Myasnikov and Marin van Heel
doi:10.1038/nature02332
First paragraph | Full Text | PDF (324K) | Supplementary information
Naturejobs
ProspectsGhosts in the machine p867
Paul Smaglik
SPECIAL REPORT
Getting mobile in Europe p868
Young scientists studying abroad often hit roadblocks when heading home. Some of these are now being cleared away, says Sally Goodman.
Sally Goodman
Career View
Graduate Journal: One of those days p870
Amber Jenkins
Scientists & Societies p870
Sylwia Gorlach and Mikolaj Slabicki