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Nature 427, 687-688 (19 February 2004) |
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Transcription: Origins of licensing control
Xue Li1 & Michael G. Rosenfeld1
Abstract
Organ development requires precise regulation of both the total number and the different types of cells. Much is known about how each process is controlled, but new light has been shed on how the two are linked.
From fertilization to maturity, a single set of genetic information must be accurately passed on to each daughter cell during the cell cycle; the mechanism involved is known as 'replication licensing'. At the same time, specialized cells and organs use unique combinations of genes, which are switched on or off by factors that control gene transcription, and this process — cell differentiation — determines the types of cell that will arise.
- Xue Li and Michael G. Rosenfeld, a Howard Hughes Medical Institute investigator, are in the School and Department of Medicine, University of California, San Diego, 9500 Gilman Drive, CMM-W345, La Jolla, California 92093-0648, USA.
Email: seli@ucsd.edu
Email: mrosenfeld@ucsd.edu
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