Supplementary information
From the following article:
Structural basis for removal of adenine mispaired with 8-oxoguanine by MutY adenine DNA glycosylase
J. Christopher Fromme, Anirban Banerjee, Susan J. Huang and Gregory L. Verdine
Nature 427, 652-656(12 February 2004)
doi:10.1038/nature02306
Supplementary figure 1: Disulfide cross-linking strategy and results.
Supplementary figure 2: Stereoview of the interactions between the enzyme and oxoG-strand of DNA.
Supplementary figure 3: MutY Sequence alignment showing the amino acid sequences from humans, the bacterium Escherichia coli (E.co.), the thermophilic bacterium Bacillus stearothermophilus (B.st., the ortholog used in this work), and the fission yeast Schizosaccharomyces pombe (S.po.).
Supplementary figure 4: Structural and crystallographic results.
Supplementary figure 5: Substrate and product adenine active site superposition.
Supplementary table: Crystallographic statistics.
Supplementary information, methods and figure legends.
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