Table of contents
Volume 427 Number 6975 pp571-660
Editorials
Budget let-downs p571
With the United States facing tough economic times, science gets small change and less sense of direction from President Bush's research and development budget proposal for 2005.
doi:10.1038/427571a
Keys to capacity p571
The task of advancing science in developing countries is beyond any one nation or organization. How can scientists help?
doi:10.1038/427571b
News
Virologists call for vaccination in bid to beat bird flu epidemic p573
Alison Abbott
doi:10.1038/427573a
Retraction signals end of cell-biology debate p574
Erika Check
doi:10.1038/427574a
NASA steels itself for rough ride over Hubble's demise p574
Tony Reichhardt
doi:10.1038/427574b
Food panel calls for beefed up response to mad cow disease p575
Erika Check
doi:10.1038/427575a
Pacific dolphins make waves for US policy on Mexican tuna p575
Virginia Gewin
doi:10.1038/427575b
Bioprospectors hunt for fair share of profits p576
Rex Dalton
doi:10.1038/427576a
Carp virus crisis prompts moves to avert global spread p577
Helen Pearson
doi:10.1038/427577a
Kofi Annan backs call for science push in developing countries p577
Declan Butler
doi:10.1038/427577b
News Features
Green explosives: Collateral damage p580
Even munitions that are never used in anger can have a long-term impact on the environment, and the military is anxious to minimize the risks. Jim Giles talks to the chemists who are developing 'green' explosives.
doi:10.1038/427580a
Climate change: The hot hand of history p582
We may not have known we were doing it, but humans have been changing the climate for thousands of years, a new theory suggests. Could our ancestors have saved us from an ice age? Betsy Mason investigates.
doi:10.1038/427582a
Correspondence
Europe needs a strategy to fight kidney disease p584
Funding would be well spent, both in human terms and in reducing the financial burden.
Peter J. Lockyer
doi:10.1038/427584a
Celebrating supernovae that changed the world p584
P. R. Vishwanath
doi:10.1038/427584b
Was Watson and Crick's model truly self-evident? p584
Stanley Scher
doi:10.1038/427584c
Books and Arts
Soul searching p585
What have advances in neuroscience told us about the mind?
Rina Knoeff reviews Soul Made Flesh: The Discovery of the Brain and How it Changed the World by Carl Zimmer
doi:10.1038/427585a
Systematic survey of the spheres p585
Doug Hamilton reviews Physics of the Solar System: Dynamics and Evolution, Space Physics, and Spacetime Structure by Bruno Bertotti , Paolo Farrinella and David Vokrouhlický
doi:10.1038/427585b
Science and the city p586
Jacqueline Reynolds and Charles Tanford review Walks around the Scientific World of Barcelona by Xavier Duran and Merce Piqueras
doi:10.1038/427586a
Performance: A visceral experience p587
Carina Dennis reviews Tulp, the Body Public
doi:10.1038/427587a
Essay
ConceptExtinction: past and present p589
The fossil record, together with modern data, can provide a deeper understanding of biological extinction and its consequences.
David Jablonski
doi:10.1038/427589a
News and Views
Particle physics: Lattice window on strong force p591
A long-awaited breakthrough has been made in lattice quantum chromodynamics — a means of calculating the effect of the strong force between sub-atomic particles that could, ultimately, unveil new physics.
Ian Shipsey
doi:10.1038/427591a
Medicine: Genetic spotlight on a blood defect p592
The causes of defects in the blood system of newborn babies can be hard to establish if the errors are not inherited. An elegant approach has identified a gene that can encourage new blood vessels to grow.
Diether Lambrechts and Peter Carmeliet
doi:10.1038/427592a
100 and 50 years ago p593
doi:10.1038/427593a
Plant ecology: Favoured aliens for the future p594
Some species of plant will prefer a world with higher levels of atmospheric carbon dioxide. When those species are invasive pests, the invaders may well flourish at the expense of the native vegetation.
Peter D. Moore
doi:10.1038/427594a
Planetary science: Magnetic Mercury p595
Tim Limcoln
doi:10.1038/427595a
Device physics: The optical age of silicon p595
The silicon chip has been the mainstay of the electronics industry and it may similarly come to dominate photonics. A key component — a high-frequency optical modulator — has now been fabricated.
Graham T. Reed
doi:10.1038/427595b
Conservation biology: Fatal medicine for vultures p596
In an echo of events that unfolded earlier in the West, declines of vulture populations in the Indian subcontinent are linked to an environmental poison. Three species of these birds approach extinction.
Robert Risebrough
doi:10.1038/nature02365
Supramolecular chemistry: Molecular merry-go-round p597
Magdalena Helmer
doi:10.1038/427597a
Molecular biology: Ensuring error-free DNA repair p598
Damaged DNA must be removed with the utmost precision, as mistakes are costly. The structure of a repair enzyme bound to its substrate provides a welcome clue to how this is achieved.
Tomas Lindahl
doi:10.1038/427598a
Correction p598
doi:10.1038/427598b
News and views in brief p599
doi:10.1038/427599a
News and Views Feature
Networking opportunity p601
A neglected mathematical theory is enjoying new popularity, thanks to its relevance to network dynamics in biological systems. The beating of a leech's heart is just one example that has a mathematical basis in 'groupoid theory'.
Ian Stewart
doi:10.1038/427601a
Brief Communications
Neuroanatomy: Brain asymmetry and long-term memory p605
Fruitflies that have structurally similar brain hemispheres forget within a matter of hours.
Alberto Pascual, Kai-Lian Huang, Julie Neveu and Thomas Préat
doi:10.1038/427605a
First paragraph | Full Text | PDF (374K) | Supplementary information
Evolutionary genetics: CCR5 mutation and plague protection p606
Joan Mecsas, Greg Franklin, William A. Kuziel, Robert R. Brubaker, Stanley Falkow and Donald E. Mosier
doi:10.1038/427606a
First paragraph | Full Text | PDF (81K)
Article
Reversible redox energy coupling in electron transfer chains p607
Artur Osyczka, Christopher C. Moser, Fevzi Daldal and P. Leslie Dutton
doi:10.1038/nature02242
Abstract | Full Text | PDF (316K) | Supplementary information
Letters to Nature
The central image of a gravitationally lensed quasar p613
Joshua N. Winn, David Rusin and Christopher S. Kochanek
doi:10.1038/nature02279
First paragraph | Full Text | PDF (155K)
A high-speed silicon optical modulator based on a metal–oxide–semiconductor capacitor p615
Ansheng Liu, Richard Jones, Ling Liao, Dean Samara-Rubio, Doron Rubin, Oded Cohen, Remus Nicolaescu and Mario Paniccia
doi:10.1038/nature02310
First paragraph | Full Text | PDF (205K)
See also: News and Views by Reed
A 1.7-kilobase single-stranded DNA that folds into a nanoscale octahedron p618
William M. Shih, Joel D. Quispe and Gerald F. Joyce
doi:10.1038/nature02307
First paragraph | Full Text | PDF (200K) | Supplementary information
Earthquake nucleation by transient deformations caused by the M = 7.9 Denali, Alaska, earthquake p621
J. Gomberg, P. Bodin, K. Larson and H. Dragert
doi:10.1038/nature02335
First paragraph | Full Text | PDF (782K)
Ramp initiation in a thrust wedge p624
John Panian and David Wiltschko
doi:10.1038/nature02334
First paragraph | Full Text | PDF (666K)
New light shed on the oldest insect p627
Michael S. Engel and David A. Grimaldi
doi:10.1038/nature02291
First paragraph | Full Text | PDF (266K)
Diclofenac residues as the cause of vulture population decline in Pakistan p630
J. Lindsay Oaks, Martin Gilbert, Munir Z. Virani, Richard T. Watson, Carol U. Meteyer, Bruce A. Rideout, H. L. Shivaprasad, Shakeel Ahmed, Muhammad Jamshed Iqbal Chaudhry, Muhammad Arshad, Shahid Mahmood, Ahmad Ali and Aleem Ahmed Khan
doi:10.1038/nature02317
First paragraph | Full Text | PDF (179K) | Supplementary information
See also: News and Views by Risebrough
An optimal bronchial tree may be dangerous p633
B. Mauroy, M. Filoche, E. R. Weibel and B. Sapoval
doi:10.1038/nature02287
First paragraph | Full Text | PDF (216K)
Susceptibility to leprosy is associated with PARK2 and PACRG p636
Marcelo T. Mira, Alexandre Alcaïs, Nguyen Van Thuc, Milton O. Moraes, Celestino Di Flumeri, Vu Hong Thai, Mai Chi Phuong, Nguyen Thu Huong, Nguyen Ngoc Ba, Pham Xuan Khoa, Euzenir N. Sarno, Andrea Alter, Alexandre Montpetit, Maria E. Moraes, José R. Moraes, Carole Doré, Caroline J. Gallant, Pierre Lepage, Andrei Verner, Esther van de Vosse, Thomas J. Hudson, Laurent Abel and Erwin Schurr
doi:10.1038/nature02326
First paragraph | Full Text | PDF (546K) | Supplementary information
Identification of an angiogenic factor that when mutated causes susceptibility to Klippel–Trenaunay syndrome p640
Xiao-Li Tian, Rajkumar Kadaba, Sun-Ah You, Mugen Liu, Ayse Anil Timur, Lin Yang, Qiuyun Chen, Przemyslaw Szafranski, Shaoqi Rao, Ling Wu, David E. Housman, Paul E. DiCorleto, David J. Driscoll, Julian Borrow and Qing Wang
doi:10.1038/nature02320
First paragraph | Full Text | PDF (718K) | Supplementary information
See also: News and Views by Lambrechts & Carmeliet
A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans p645
Scott Kennedy, Duo Wang and Gary Ruvkun
doi:10.1038/nature02302
First paragraph | Full Text | PDF (324K) | Supplementary information
Cytoplasmic dynein functions as a gear in response to load p649
Roop Mallik, Brian C. Carter, Stephanie A. Lex, Stephen J. King and Steven P. Gross
doi:10.1038/nature02293
First paragraph | Full Text | PDF (1,495K) | Supplementary information
Structural basis for removal of adenine mispaired with 8-oxoguanine by MutY adenine DNA glycosylase p652
J. Christopher Fromme, Anirban Banerjee, Susan J. Huang and Gregory L. Verdine
doi:10.1038/nature02306
First paragraph | Full Text | PDF (332K) | Supplementary information
See also: News and Views by
Naturejobs
ProspectsPatching a leaky pipeline p657
Paul Smaglik
doi:10.1038/nj6975-657a
REGIONS
Baywatch: San Francisco p658
Paul Smaglik
doi:10.1038/nj6975-658a
Career View
Graduate Journal: Seeking perspective p660
Philipp Angerer
doi:10.1038/nj6975-660a
Bricks & Mortar p660
Sally Goodman
doi:10.1038/nj6975-660b
Movers p660
doi:10.1038/nj6975-660c