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Nature 427, 541-544 (5 February 2004) | doi:10.1038/nature02254;
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Identification of the gene for vitamin K epoxide reductase
Vitamin K epoxide reductase (VKOR) is the target of warfarin, the most widely prescribed anticoagulant for thromboembolic disorders. Although estimated to prevent twenty strokes per induced bleeding episode, warfarin is under-used because of the difficulty of controlling dosage and the fear of inducing bleeding.
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