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Nature 427, 537-541 (5 February 2004) | doi:10.1038/nature02214;
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Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2
Coumarin derivatives such as warfarin represent the therapy of choice for the long-term treatment and prevention of thromboembolic events. Coumarins target blood coagulation by inhibiting the vitamin K epoxide reductase multiprotein complex (VKOR).
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