Access
To read this story in full you will need to login or make a payment (see right).
Brief Communications
Nature 427, 504 (5 February 2004) | doi:10.1038/427504a
Open Innovation Challenges
-
Optimizing Sub-cellular Localization Tags
The Seeker is looking for methods to optimize sub-cellular localization tags for protein expression....
-
Direct Molecular Detection of Proteins and Nucleic Acids
This Challenge is looking for novel approaches to protein and nucleic acid detection. This is an Id...
nature jobs
.Net
- Indegene Lifesystems Pvt. Ltd
- Bengaluru 560 071 India
Group Leader Positions
- IMP
- Vienna Austria
Transgenic mice: Fat-1 mice convert n-6 to n-3 fatty acids
Jing X. Kang1, Jingdong Wang1, Lin Wu2 & Zhao B. Kang1
Abstract
Mammals cannot naturally produce omega-3 (n-3) fatty acids — beneficial nutrients found mainly in fish oil — from the more abundant omega-6 (n-6) fatty acids and so they must rely on a dietary supply1. Here we show that mice engineered to carry a fat-1 gene from the roundworm Caenorhabditis elegans can add a double bond into an unsaturated fatty-acid hydrocarbon chain and convert n-6 to n-3 fatty acids. This results in an abundance of n-3 and a reduction in n-6 fatty acids in the organs and tissues of these mice, in the absence of dietary n-3. As well as presenting an opportunity to investigate the roles played by n-3 fatty acids in the body, our discovery indicates that this technology might be adapted to enrich n-3 fatty acids in animal products such as meat, milk and eggs.
To read this story in full you will need to login or make a payment (see right).
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
RESEARCH
Effect of fasudil on Rho-kinase and nephropathy in subtotally nephrectomized spontaneously hypertensive ratsKidney International Original Article
Generation of cloned transgenic pigs rich in omega-3 fatty acidsNature Biotechnology Research (01 Apr 2006)
Stepwise engineering to produce high yields of very long-chain polyunsaturated fatty acids in plantsNature Biotechnology Research (01 Aug 2005)
Increased dietary intake of ω-3-polyunsaturated fatty acids reduces pathological retinal angiogenesisNature Medicine Letter (01 Jul 2007)
See all 51 matches for Research
