FIGURE 3. Subcellular location of VKORC1.
From the following article:
Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2
Simone Rost, Andreas Fregin, Vytautas Ivaskevicius, Ernst Conzelmann, Konstanze Hörtnagel, Hans-Joachim Pelz, Knut Lappegard, Erhard Seifried, Inge Scharrer, Edward G. D. Tuddenham, Clemens R. Müller, Tim M. Strom and Johannes Oldenburg
Nature 427, 537-541(5 February 2004)
doi:10.1038/nature02214
COS-7 cells transiently transfected with constructs expressing VKORC1 were stained with anti-calnexin (red; left column) and anti-GFP or anti-Myc, respectively (green; middle column). Merged images of the double-stained cells are shown on the right. Both VKORC1 constructs (tagged with GFP or Myc) colocalize with the ER-specific calnexin staining, whereas the control construct (pEGFP-N1) shows a diffuse pattern of staining throughout the cytoplasm.
