FIGURE 2. Amino acid sequence alignment of VKORC1 and VKORC1L1.
From the following article:
Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2
Simone Rost, Andreas Fregin, Vytautas Ivaskevicius, Ernst Conzelmann, Konstanze Hörtnagel, Hans-Joachim Pelz, Knut Lappegard, Erhard Seifried, Inge Scharrer, Edward G. D. Tuddenham, Clemens R. Müller, Tim M. Strom and Johannes Oldenburg
Nature 427, 537-541(5 February 2004)
doi:10.1038/nature02214
The alignment was generated with ClustalW and Prettybox. Human, mouse and rat VKORC1 and VKORC1L1 proteins share roughly 84% and 97% identity, respectively, and there is about 50% identity between the two groups of proteins. Homologues were also detected in Xenopus laevis and Anopheles gambiae. The proteins are labelled by their gene symbols or accession codes and a prefix indicating the species (Hs, H. sapiens; Mm, M. musculus; Rn, R. norvegicus; Fr, Fugu rubripes; Xl, X. laevis; Ag, A. gambiae). Predicted transmembrane domains are indicated by bold lines. Residues 29, 58 and 128 (+ ), which are mutated in individuals with WR, and residue 139 (#), which is mutated in Rw rats, are conserved in all species. WR mutation Val45Ala (+ ) and Arg 98 (*), which is mutated in individuals with VKCFD2, are conserved in human, rat and mouse VKORC1.
