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Nature 427, 307-308 (22 January 2004) | doi:10.1038/427307a
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Gastrointestinal Pathologist
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Virology: A class act
Theodore S. Jardetzky1 & Robert A. Lamb1
Abstract
Membrane fusion occurs in many situations in living organisms — when certain viruses enter host cells, for instance. Three crystal structures shed light on the protein rearrangements that bring about such fusion.
Many viruses, such as the dengue fever, influenza and human immunodeficiency viruses, are encased in a lipid membrane. To reproduce, such 'enveloped' viruses must enter a host cell by fusing their own membrane coat with that of the cell.
- Theodore S. Jardetzky and Robert A. Lamb are in the Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois 60208-3500, USA.
Correspondence to: Theodore S. Jardetzky1 Email: tedj@northwestern.edu
Correspondence to: Robert A. Lamb1 Email: ralamb@northwestern.edu
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NEWS AND VIEWS
Implications of a fusion peptide structureNature Structural Biology News and Views (01 Aug 2001)
RESEARCH
Structure of the dengue virus envelope protein after membrane fusionNature Article (22 Jan 2004)
Structure of the parainfluenza virus 5 F protein in its metastable, prefusion conformationNature Article (05 Jan 2006)
Conformational change and protein?protein interactions of the fusion protein of Semliki Forest virusNature Article (22 Jan 2004)
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