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Nature 427, 148-154 (10 December 2003) | doi:10.1038/nature02247;
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Derivation of embryonic germ cells and male gametes from embryonic stem cells
Egg and sperm cells (gametes) of the mouse are derived from a founder population of primordial germ cells that are set aside early in embryogenesis. Primordial germ cells arise from the proximal epiblast, a region of the early mouse embryo that also contributes to the first blood lineages of the embryonic yolk sac.
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