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Nature 427, 110-111 (8 January 2004) | doi:10.1038/427110a
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Research Assistant / Associate
- University of Glasgow
- Glasgow, UK
Cancer: Guarding the guardian?
Henning F. Horn1 & Karen H. Vousden1
Abstract
The diversity of cellular stresses that activate the 'guardian of the genome' — p53 — begs the question of how these signals all converge on one protein. Perhaps the key to this integration is the nucleolus.
If there is beauty in simplicity then the p53 protein is unlikely to win any contests. As one of our key defences against cancer, p53 lies at the heart of a massive research effort that has generated an avalanche of papers.
- Beatson Institute for Cancer Research, Switchback Road, Glasgow G61 1BD, UK.
Correspondence to: Karen H. Vousden1 Email: k.vousden@beatson.gla.ac.uk
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RESEARCH
Energy-dependent nucleolar localization of p53 in vitro requires two discrete regions within the p53 carboxyl terminusOncogene Original Article
PML regulates p53 stability by sequestering Mdm2 to the nucleolusNature Cell Biology Letter (01 Jul 2004)
Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stressesThe EMBO Journal Article (17 Nov 2003)
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