Access
To read this story in full you will need to login or make a payment (see right).
Insight
Nature 426, 905-909 (18 December 2003) | doi:10.1038/nature02265
Review article Therapeutic approaches to protein-misfolding diseases
Fred E. Cohen1 & Jeffery W. Kelly2
Abstract
Several sporadic and genetic diseases are caused by protein misfolding. These include cystic fibrosis and other devastating diseases of childhood as well as Alzheimer's, Parkinson's and other debilitating maladies of the elderly. A unified view of the molecular and cellular pathogenesis of these conditions has led to the search for chemical chaperones that can slow, arrest or revert disease progression. Molecules are now emerging that link our biophysical insights with our therapeutic aspirations.
To read this story in full you will need to login or make a payment (see right).