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Nature 426, 671-676 (11 December 2003) | doi:10.1038/nature02067;
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- Surrey, United kindom
Clinical Pharmacologist or Medical Toxicologist
- University of Arkansas for Medical Sciences-Department of Pediatrics
- Little Rock, AR
Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1
Regulated apoptosis is essential for both the development and the subsequent maintenance of the immune system. Interleukins, including IL-2, IL-4, IL-7 and IL-15, heavily influence lymphocyte survival during the vulnerable stages of VDJ rearrangement and later in ensuring cellular homeostasis, but the genes specifically responsible for the development and maintenance of lymphocytes have not been identified.
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