Access

Brief Communications

Nature 426, 620 (11 December 2003) | doi:10.1038/426620a

Open Innovation Challenges

  • Optimizing Sub-cellular Localization Tags

    • Deadline: Jan 31 2010
    • Reward: $20,000 USD

    The Seeker is looking for methods to optimize sub-cellular localization tags for protein expression....

  • Single-cell Analysis Platform

    • Deadline: Dec 02 2009
    • Reward: $5,000 USD

    This Challenge is looking for novel approaches to analyzing changes at a single-cell level. This is...

naturejobs

Genetics: Influence of TOR kinase on lifespan in C. elegans

Tibor Vellai1, Krisztina Takacs-Vellai1, Yue Zhang1, Attila L. Kovacs2, László Orosz3,4 & Fritz Müller1

Top

The group of enzymes known as TOR (for 'target of rapamycin') kinases regulates cell growth and proliferation in response to nutrients and hormone-dependent mitogenic signals1, 2. Here we show that TOR deficiency in the nematode Caenorhabditis elegans more than doubles its natural lifespan. This new function for TOR signalling in ageing control may represent a link between nutrition, metabolism and longevity.