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Brief Communications
Nature 426, 620 (11 December 2003) | doi:10.1038/426620a
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Genetics: Influence of TOR kinase on lifespan in C. elegans
Tibor Vellai1, Krisztina Takacs-Vellai1, Yue Zhang1, Attila L. Kovacs2, László Orosz3,4 & Fritz Müller1
Abstract
The group of enzymes known as TOR (for 'target of rapamycin') kinases regulates cell growth and proliferation in response to nutrients and hormone-dependent mitogenic signals1, 2. Here we show that TOR deficiency in the nematode Caenorhabditis elegans more than doubles its natural lifespan. This new function for TOR signalling in ageing control may represent a link between nutrition, metabolism and longevity.
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