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Nature 426, 614-615 (11 December 2003) | doi:10.1038/426614a

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Signal transduction: Molecular monogamy

Drew Endy1 & Michael B. Yaffe1

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The interactions between cellular proteins must be highly specific, or cells will stop functioning. Some clever protein-manipulation experiments have revealed how this specificity has evolved in yeast.

If an integrated system is to function correctly, its components must be wired together accurately. This requirement presents a particular challenge for living cells, because cellular components move about and intermix, and because the 'wires' themselves are dynamic molecular interactions.

  1. Drew Endy and Michael B. Yaffe are in the Department of Biology and the Division of Biological Engineering, and Michael B. Yaffe is at the Center for Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139-4307, USA.

Correspondence to: Michael B. Yaffe1 Email: myaffe@mit.edu