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TY  - JOUR
AU  - Malliri, A.
TI  - Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours
JO  - Nature
PY  - 2002///
VL  - 417
SP  - 867
EP  - 871
M3  - 10.1038/nature00848
N1  - 10.1038/nature00848
UR  - http://dx.doi.org/10.1038/nature00848
ER  - 

TY  - JOUR
AU  - Donaldson, J. G.
AU  - Finazzi, D.
AU  - Klausner, R. D.
TI  - Brefeldin A inhibits Golgi membrane-catalysed exchange of guanine nucleotide onto ARF protein
JO  - Nature
PY  - 1992///
VL  - 360
SP  - 350
EP  - 352
M3  - 10.1038/360350a0
N1  - 10.1038/360350a0
UR  - http://dx.doi.org/10.1038/360350a0
ER  - 

TY  - JOUR
AU  - Helms, J. B.
AU  - Rothman, J. E.
TI  - Inhibition by brefeldin A of a Golgi membrane enzyme that catalyses exchange of guanine nucleotide bound to ARF
JO  - Nature
PY  - 1992///
VL  - 360
SP  - 352
EP  - 354
M3  - 10.1038/360352a0
N1  - 10.1038/360352a0
UR  - http://dx.doi.org/10.1038/360352a0
ER  - 

TY  - JOUR
AU  - Peyroche, A.
TI  - Brefeldin A acts to stabilize an abortive ARF-GDP-Sec7 domain protein complex: involvement of specific residues of the Sec7 domain
JO  - Mol. Cell
PY  - 1999///
VL  - 3
SP  - 275
EP  - 285
M3  - 10.1016/S1097-2765(00)80455-4
N1  - 10.1016/S1097-2765(00)80455-4
UR  - http://dx.doi.org/10.1016/S1097-2765(00)80455-4
ER  - 

TY  - JOUR
AU  - Mayer, G.
TI  - Controlling small guanine-nucleotide-exchange factor function through cytoplasmic RNA intramers
JO  - Proc. Natl Acad. Sci. USA
PY  - 2001///
VL  - 98
SP  - 4961
EP  - 4965
M3  - 10.1073/PNAS.091100698
N1  - 10.1073/PNAS.091100698
UR  - http://dx.doi.org/10.1073/PNAS.091100698
ER  - 

TY  - JOUR
AU  - Schmidt, S.
AU  - Diriong, S.
AU  - Mery, J.
AU  - Fabbrizio, E.
AU  - Debant, A.
TI  - Identification of the first Rho-GEF inhibitor, TRIP[alpha], which targets the RhoA-specific GEF domain of Trio
JO  - FEBS Lett.
PY  - 2002///
VL  - 523
SP  - 35
EP  - 42
M3  - 10.1016/S0014-5793(02)02928-9
N1  - 10.1016/S0014-5793(02)02928-9
UR  - http://dx.doi.org/10.1016/S0014-5793(02)02928-9
ER  - 

TY  - JOUR
AU  - Klebe, C.
AU  - Prinz, H.
AU  - Wittinghofer, A.
AU  - Goody, R. S.
TI  - The kinetic mechanism of Ran-nucleotide exchange catalyzed by RCC1
JO  - Biochemistry
PY  - 1995///
VL  - 34
SP  - 12543
EP  - 12552
M3  - 10.1021/bi00039a008
N1  - 10.1021/bi00039a008
UR  - http://dx.doi.org/10.1021/bi00039a008
ER  - 

TY  - JOUR
AU  - Lenzen, C.
AU  - Cool, R. H.
AU  - Prinz, H.
AU  - Kuhlmann, J.
AU  - Wittinghofer, A.
TI  - Kinetic analysis by fluorescence of the interaction between Ras and the catalytic domain of the guanine nucleotide exchange factor Cdc25Mm
JO  - Biochemistry
PY  - 1998///
VL  - 37
SP  - 7420
EP  - 7430
M3  - 10.1021/bi972621j
N1  - 10.1021/bi972621j
UR  - http://dx.doi.org/10.1021/bi972621j
ER  - 

TY  - JOUR
AU  - Goody, R. S.
AU  - Hofmann-Goody, W.
TI  - Exchange factors, effectors, GAPs and motor proteins: common thermodynamic and kinetic principles for different functions
JO  - Eur. Biophys. J.
PY  - 2002///
VL  - 31
SP  - 268
EP  - 274
M3  - 10.1007/s00249-002-0225-3
N1  - 10.1007/s00249-002-0225-3
UR  - http://dx.doi.org/10.1007/s00249-002-0225-3
ER  - 

TY  - JOUR
AU  - Boriack-Sjodin, P. A.
AU  - Margarit, S. M.
AU  - Bar-Sagi, D.
AU  - Kuriyan, J.
TI  - The structural basis of the activation of Ras by Sos
JO  - Nature
PY  - 1998///
VL  - 394
SP  - 337
EP  - 343
M3  - 10.1038/28548
N1  - 10.1038/28548
UR  - http://dx.doi.org/10.1038/28548
ER  - 

TY  - JOUR
AU  - Goldberg, J.
TI  - Structural basis for activation of ARF GTPase: mechanisms of guanine nucleotide exchange and GTP-myristoyl switching
JO  - Cell
PY  - 1998///
VL  - 95
SP  - 237
EP  - 248
M3  - 10.1016/S0092-8674(00)81754-7
N1  - 10.1016/S0092-8674(00)81754-7
UR  - http://dx.doi.org/10.1016/S0092-8674(00)81754-7
ER  - 

TY  - JOUR
AU  - Worthylake, D. K.
AU  - Rossman, K. L.
AU  - Sondek, J.
TI  - Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1
JO  - Nature
PY  - 2000///
VL  - 408
SP  - 682
EP  - 688
M3  - 10.1038/35047014
N1  - 10.1038/35047014
UR  - http://dx.doi.org/10.1038/35047014
ER  - 

TY  - JOUR
AU  - Renault, L.
AU  - Kuhlmann, J.
AU  - Henkel, A.
AU  - Wittinghofer, A.
TI  - Structural basis for guanine nucleotide exchange on Ran by the regulator of chromosome condensation (RCC1)
JO  - Cell
PY  - 2001///
VL  - 105
SP  - 245
EP  - 255
M3  - 10.1016/S0092-8674(01)00315-4
N1  - 10.1016/S0092-8674(01)00315-4
UR  - http://dx.doi.org/10.1016/S0092-8674(01)00315-4
ER  - 

TY  - JOUR
AU  - Nie, Z.
AU  - Hirsch, D. S.
AU  - Randazzo, P. A.
TI  - Arf and its many interactors
JO  - Curr. Opin. Cell Biol.
PY  - 2003///
VL  - 15
SP  - 396
EP  - 404
M3  - 10.1016/S0955-0674(03)00071-1
N1  - 10.1016/S0955-0674(03)00071-1
UR  - http://dx.doi.org/10.1016/S0955-0674(03)00071-1
ER  - 

TY  - JOUR
AU  - Beraud-Dufour, S.
TI  - A glutamic finger in the guanine nucleotide exchange factor ARNO displaces Mg2+ and the [beta]-phosphate to destabilize GDP on ARF1
JO  - EMBO J.
PY  - 1998///
VL  - 17
SP  - 3651
EP  - 3659
M3  - 10.1093/emboj/17.13.3651
N1  - 10.1093/emboj/17.13.3651
UR  - http://dx.doi.org/10.1093/emboj/17.13.3651
ER  - 

TY  - JOUR
AU  - Vetter, I. R.
AU  - Wittinghofer, A.
TI  - The guanine nucleotide-binding switch in three dimensions
JO  - Science
PY  - 2001///
VL  - 294
SP  - 1299
EP  - 1304
M3  - 10.1126/SCIENCE.1062023
N1  - 10.1126/SCIENCE.1062023
UR  - http://dx.doi.org/10.1126/SCIENCE.1062023
ER  - 

TY  - JOUR
AU  - Pasqualato, S.
AU  - Renault, L.
AU  - Cherfils, J.
TI  - Arf, Arl, Arp and Sar proteins: a family of GTP-binding proteins with a structural device for `front-back' communication
JO  - EMBO Rep.
PY  - 2002///
VL  - 3
SP  - 1035
EP  - 1041
M3  - 10.1093/embo-reports/kvf221
N1  - 10.1093/embo-reports/kvf221
UR  - http://dx.doi.org/10.1093/embo-reports/kvf221
ER  - 

TY  - JOUR
AU  - Amor, J. C.
AU  - Harrison, D. H.
AU  - Kahn, R. A.
AU  - Ringe, D.
TI  - Structure of the human ADP-ribosylation factor 1 complexed with GDP
JO  - Nature
PY  - 1994///
VL  - 372
SP  - 704
EP  - 708
M3  - 10.1038/372704a0
N1  - 10.1038/372704a0
UR  - http://dx.doi.org/10.1038/372704a0
ER  - 

TY  - JOUR
AU  - Menetrey, J.
AU  - Macia, E.
AU  - Pasqualato, S.
AU  - Franco, M.
AU  - Cherfils, J.
TI  - Structure of Arf6-GDP suggests a basis for guanine nucleotide exchange factors specificity
JO  - Nature Struct. Biol.
PY  - 2000///
VL  - 7
SP  - 466
EP  - 469
M3  - 10.1038/75863
N1  - 10.1038/75863
UR  - http://dx.doi.org/10.1038/75863
ER  - 

TY  - JOUR
AU  - Antonny, B.
AU  - Beraud-Dufour, S.
AU  - Chardin, P.
AU  - Chabre, M.
TI  - N-terminnal hydrophobic residues of the G-protein ADP-ribosylation factor-1 insert into membrane phospholipids upon GDP to GTP exchange
JO  - Biochemistry
PY  - 1997///
VL  - 36
SP  - 4675
EP  - 4684
M3  - 10.1021/bi962252b
N1  - 10.1021/bi962252b
UR  - http://dx.doi.org/10.1021/bi962252b
ER  - 

TY  - JOUR
AU  - Jackson, C. L.
AU  - Casanova, J. E.
TI  - Turning on ARF: the Sec7 family of guanine-nucleotide-exchange factors
JO  - Trends Cell Biol.
PY  - 2000///
VL  - 10
SP  - 60
EP  - 67
M3  - 10.1016/S0962-8924(99)01699-2
N1  - 10.1016/S0962-8924(99)01699-2
UR  - http://dx.doi.org/10.1016/S0962-8924(99)01699-2
ER  - 

TY  - JOUR
AU  - Cherfils, J.
TI  - Structure of the Sec7 domain of the Arf exchange factor ARNO
JO  - Nature
PY  - 1998///
VL  - 392
SP  - 101
EP  - 105
M3  - 10.1038/32210
N1  - 10.1038/32210
UR  - http://dx.doi.org/10.1038/32210
ER  - 

TY  - JOUR
AU  - Mansour, S. J.
TI  - p200 ARF-GEP1: a Golgi-localized guanine nucleotide exchange protein whose Sec7 domain is targeted by the drug brefeldin A
JO  - Proc. Natl Acad. Sci. USA
PY  - 1999///
VL  - 96
SP  - 7968
EP  - 7973
M3  - 10.1073/pnas.96.14.7968
N1  - 10.1073/pnas.96.14.7968
UR  - http://dx.doi.org/10.1073/pnas.96.14.7968
ER  - 

TY  - JOUR
AU  - Jackson, C. L.
TI  - Brefeldin A revealing the fundamental principles governing membrane dynamics and protein transport
JO  - Subcell. Biochem.
PY  - 2000///
VL  - 34
SP  - 233
EP  - 272
ER  - 

TY  - JOUR
AU  - Zhu, J. W.
TI  - Elucidation of strict structural requirements of brefeldin A as an inducer of differentiation and apoptosis
JO  - Bioorg. Med. Chem.
PY  - 2000///
VL  - 8
SP  - 455
EP  - 463
M3  - 10.1016/S0968-0896(99)00297-7
N1  - 10.1016/S0968-0896(99)00297-7
UR  - http://dx.doi.org/10.1016/S0968-0896(99)00297-7
ER  - 

TY  - JOUR
AU  - Chardin, P.
TI  - A human exchange factor for ARF contains Sec7- and pleckstrin-homology domains
JO  - Nature
PY  - 1996///
VL  - 384
SP  - 481
EP  - 484
M3  - 10.1038/384481a0
N1  - 10.1038/384481a0
UR  - http://dx.doi.org/10.1038/384481a0
ER  - 

TY  - JOUR
AU  - Claude, A.
TI  - GBF1: A novel Golgi-associated BFA-resistant guanine nucleotide exchange factor that displays specificity for ADP-ribosylation factor 5
JO  - J. Cell Biol.
PY  - 1999///
VL  - 146
SP  - 71
EP  - 84
ER  - 

TY  - JOUR
AU  - Donaldson, J. G.
AU  - Jackson, C. L.
TI  - Regulators and effectors of the ARF GTPases
JO  - Curr. Opin. Cell Biol.
PY  - 2000///
VL  - 12
SP  - 475
EP  - 482
M3  - 10.1016/S0955-0674(00)00119-8
N1  - 10.1016/S0955-0674(00)00119-8
UR  - http://dx.doi.org/10.1016/S0955-0674(00)00119-8
ER  - 

TY  - JOUR
AU  - Donaldson, J. G.
TI  - Multiple roles for Arf6: Sorting, structuring, and signaling at the plasma membrane
JO  - J. Biol. Chem.
PY  - 2003///
VL  - 11
SP  - 41573
EP  - 41576
M3  - 10.1074/jbc.R300026200
N1  - 10.1074/jbc.R300026200
UR  - http://dx.doi.org/10.1074/jbc.R300026200
ER  - 

TY  - JOUR
AU  - Sata, M.
AU  - Moss, J.
AU  - Vaughan, M.
TI  - Structural basis for the inhibitory effect of brefeldin A on guanine nucleotide-exchange proteins for ADP-ribosylation factors
JO  - Proc. Natl Acad. Sci. USA
PY  - 1999///
VL  - 96
SP  - 2752
EP  - 2757
M3  - 10.1073/pnas.96.6.2752
N1  - 10.1073/pnas.96.6.2752
UR  - http://dx.doi.org/10.1073/pnas.96.6.2752
ER  - 

TY  - JOUR
AU  - Baumgartner, F.
AU  - Wiek, S.
AU  - Paprotka, K.
AU  - Zauner, S.
AU  - Lingelbach, K.
TI  - A point mutation in an unusual Sec7 domain is linked to brefeldin A resistance in a Plasmodium falciparum line generated by drug selection
JO  - Mol. Microbiol.
PY  - 2001///
VL  - 41
SP  - 1151
EP  - 1158
M3  - 10.1046/j.1365-2958.2001.02572.x
N1  - 10.1046/j.1365-2958.2001.02572.x
UR  - http://dx.doi.org/10.1046/j.1365-2958.2001.02572.x
ER  - 

TY  - JOUR
AU  - Robineau, S.
AU  - Chabre, M.
AU  - Antonny, B.
TI  - Binding site of brefeldin A at the interface between the small G protein ADP-ribosylation factor 1 (ARF1) and the nucleotide-exchange factor Sec7 domain
JO  - Proc. Natl Acad. Sci. USA
PY  - 2000///
VL  - 97
SP  - 9913
EP  - 9918
M3  - 10.1073/pnas.170290597
N1  - 10.1073/pnas.170290597
UR  - http://dx.doi.org/10.1073/pnas.170290597
ER  - 

TY  - JOUR
AU  - Chardin, P.
AU  - McCormick, F.
TI  - Brefeldin A: the advantage of being uncompetitive
JO  - Cell
PY  - 1999///
VL  - 97
SP  - 153
EP  - 155
M3  - 10.1016/S0092-8674(00)80724-2
N1  - 10.1016/S0092-8674(00)80724-2
UR  - http://dx.doi.org/10.1016/S0092-8674(00)80724-2
ER  - 

TY  - JOUR
AU  - Beraud-Dufour, S.
AU  - Paris, S.
AU  - Chabre, M.
AU  - Antonny, B.
TI  - Dual interaction of ADP ribosylation factor 1 with Sec7 domain and with lipid membranes during catalysis of guanine nucleotide exchange
JO  - J. Biol. Chem.
PY  - 1999///
VL  - 274
SP  - 37629
EP  - 37636
M3  - 10.1074/jbc.274.53.37629
N1  - 10.1074/jbc.274.53.37629
UR  - http://dx.doi.org/10.1074/jbc.274.53.37629
ER  - 

TY  - JOUR
AU  - Renault, L.
AU  - Christova, P.
AU  - Guibert, B.
AU  - Pasqualato, S.
AU  - Cherfils, J.
TI  - Mechanism of domain closure of Sec7 domains and role in BFA sensitivity
JO  - Biochemistry
PY  - 2002///
VL  - 41
SP  - 3605
EP  - 3612
M3  - 10.1021/bi012123h
N1  - 10.1021/bi012123h
UR  - http://dx.doi.org/10.1021/bi012123h
ER  - 

TY  - JOUR
AU  - Weber, H. P.
AU  - Hauser, D.
AU  - Sigg, H. P.
TI  - Structure of brefeldin A
JO  - Helv. Chim. Acta
PY  - 1971///
VL  - 54
SP  - 2763
EP  - 2766
M3  - 10.1002/hlca.19710540839
N1  - 10.1002/hlca.19710540839
UR  - http://dx.doi.org/10.1002/hlca.19710540839
ER  - 

TY  - JOUR
AU  - Torii, S.
TI  - Cytotoxicity of brefeldin A correlates with its inhibitory effect on membrane binding of COP coat proteins
JO  - J. Biol. Chem.
PY  - 1995///
VL  - 270
SP  - 11574
EP  - 11580
M3  - 10.1074/jbc.270.19.11574
N1  - 10.1074/jbc.270.19.11574
UR  - http://dx.doi.org/10.1074/jbc.270.19.11574
ER  - 

TY  - GEN
AU  - Pasqualato, S.
AU  - Renault, L.
AU  - Cherfils, J.
TI  - The ARF Book
PY  - ///
ER  - 

TY  - JOUR
AU  - McCormick, F.
TI  - Small-molecule inhibitors of cell signaling
JO  - Curr. Opin. Biotechnol.
PY  - 2000///
VL  - 11
SP  - 593
EP  - 597
M3  - 10.1016/S0958-1669(00)00149-X
N1  - 10.1016/S0958-1669(00)00149-X
UR  - http://dx.doi.org/10.1016/S0958-1669(00)00149-X
ER  - 

TY  - JOUR
AU  - Wurtele, M.
AU  - Jelich-Ottmann, C.
AU  - Wittinghofer, A.
AU  - Oecking, C.
TI  - Structural view of a fungal toxin acting on a 14-3-3 regulatory complex
JO  - EMBO J.
PY  - 2003///
VL  - 22
SP  - 987
EP  - 994
ER  - 

TY  - JOUR
AU  - Choi, J.
AU  - Chen, J.
AU  - Schreiber, S. L.
AU  - Clardy, J.
TI  - Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP
JO  - Science
PY  - 1996///
VL  - 273
SP  - 239
EP  - 242
ER  - 

TY  - JOUR
AU  - Cherfils, J.
TI  - Structural mimicry of DH domains by Arfaptin suggests a model for the recognition of Rac-GDP by its guanine nucleotide exchange factors
JO  - FEBS Lett.
PY  - 2001///
VL  - 507
SP  - 280
EP  - 284
M3  - 10.1016/S0014-5793(01)02970-2
N1  - 10.1016/S0014-5793(01)02970-2
UR  - http://dx.doi.org/10.1016/S0014-5793(01)02970-2
ER  - 

TY  - JOUR
AU  - Cox, A. D.
AU  - Der, C. J.
TI  - Ras family signaling: therapeutic targeting
JO  - Cancer Biol. Ther.
PY  - 2002///
VL  - 1
SP  - 599
EP  - 606
ER  - 

TY  - JOUR
AU  - Boettner, B.
AU  - Van Aelst, L.
TI  - The role of Rho GTPases in disease development
JO  - Gene
PY  - 2002///
VL  - 286
SP  - 155
EP  - 174
M3  - 10.1016/S0378-1119(02)00426-2
N1  - 10.1016/S0378-1119(02)00426-2
UR  - http://dx.doi.org/10.1016/S0378-1119(02)00426-2
ER  - 

TY  - JOUR
AU  - Jones, T. A.
AU  - Zou, J. Y.
AU  - Cowan, S. W.
AU  - Kjeldgaard, M.
TI  - Improved methods for building protein models in electron density maps and the location of errors in these models
JO  - Acta Crystallogr. A
PY  - 1991///
VL  - 47
SP  - 110
EP  - 119
M3  - 10.1107/S0108767390010224
N1  - 10.1107/S0108767390010224
UR  - http://dx.doi.org/10.1107/S0108767390010224
ER  - 

