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Nature 426, 512-513 (4 December 2003) | doi:10.1038/426512a
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Medicine: Taking apart a cancer protein
Pier Paolo Scaglioni & Pier Paolo Pandolfi
Abstract
Generation of a particular 'fusion' protein is characteristic of one type of leukaemia. But is it in fact the cleavage of this protein into smaller parts that is important? Provocative new findings suggest that it is.
Cancers develop when genetic mistakes accumulate, causing cells to proliferate unchecked and to show a reluctance to die when required. In many human leukaemias, one of the initial genetic errors is a chromosomal translocation: one part of a chromosome fuses with another, creating a composite gene with unusual properties.
- Pier Paolo Scaglioni and Pier Paolo Pandolfi are in the Molecular Biology Program, Departments of Medicine and of Pathology, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.
Correspondence to: Pier Paolo Pandolfi Email: p-pandolfi@ski.mskcc.org
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