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Review
Nature 426, 517-524 (4 December 2003) | doi:10.1038/nature02196
Open Innovation Challenges
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Director of NMR
- New York Structural Biology Center
- New York, New York
Gastroenterologist
- Florida Gastroenterology Practice
- Florida, USA
TRP channels as cellular sensors
David E. Clapham
Abstract
TRP channels are the vanguard of our sensory systems, responding to temperature, touch, pain, osmolarity, pheromones, taste and other stimuli. But their role is much broader than classical sensory transduction. They are an ancient sensory apparatus for the cell, not just the multicellular organism, and they have been adapted to respond to all manner of stimuli, from both within and outside the cell.
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