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Nature 426, 241 (20 November 2003) | doi:10.1038/426241a
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John Innes Centre Project Leader in Plant or Microbial Sciences
- University of East Anglia
- Norwich, NR4 7TJ, UK
Head-Preclinical
- Syngene International
- Bangalore, Karnataka 560099 India
Developmental biology: Gender benders
Peter Koopman1
Abstract
A painstaking triple-gene-knockout study has revealed a crucial role for insulin receptors in male sexual development. But is multiple-gene targeting the way forward for analysing genome function in mammals?
The essential differences between the sexes seem constantly to perplex and beguile us. In mammals such as humans it's all down to the Y chromosome, of course: one either inherits it from one's father or one does not.
- Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland 4072, Australia.
Email: p.koopman@imb.uq.edu.au
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