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Nature 426, 241 (20 November 2003) | doi:10.1038/426241a

Open Innovation Challenges

Developmental biology: Gender benders

Peter Koopman1

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A painstaking triple-gene-knockout study has revealed a crucial role for insulin receptors in male sexual development. But is multiple-gene targeting the way forward for analysing genome function in mammals?

The essential differences between the sexes seem constantly to perplex and beguile us. In mammals such as humans it's all down to the Y chromosome, of course: one either inherits it from one's father or one does not.

  1. Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland 4072, Australia.
    Email: p.koopman@imb.uq.edu.au