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From the following article:

Testis determination requires insulin receptor family function in mice

Serge Nef, Sunita Verma-Kurvari, Jussi Merenmies, Jean-Dominique Vassalli, Argiris Efstratiadis, Domenico Accili and Luis F. Parada

Nature 426, 291-295(20 November 2003)

doi:10.1038/nature02059

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Figure 1 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com

Figure 1

Mice lacking Ir, Irr and Igf1r show complete gonadal sex reversal at the histological level.

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Figure 2

Mice lacking Ir, Irr and Igf1r show complete gonadal sex reversal at the molecular level.

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Figure 3

Insulin family signalling is required for early male gonad differentiation.

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Figure 4

Male-to-female sex reversal phenotype is variable in Ir Igf1r double mutant and in compound heterozygous Ir+/-Igf1r-/-Irr-/- mutant mice.

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