FIGURE 4. BMDCs fuse with cells in the heart.

From the following article:

Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes

Manuel Alvarez-Dolado, Ricardo Pardal, Jose M. Garcia-Verdugo, John R. Fike, Hyun O. Lee, Klaus Pfeffer, Carlos Lois, Sean J. Morrison and Arturo Alvarez-Buylla

Nature 425, 968-973(30 October 2003)

doi:10.1038/nature02069

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ad, Sections at 50 microm (a), 1.5 microm (b, c) and electron microscopy (d) sections showing a beta-gal+ cardiomyocyte in a R26R mouse transplanted with beta-actin-Cre–GFP-expressing bone marrow cells. Note that beta-gal+ cardiomyocytes follow the orientation of other fibres. e, Electron microscopy photomicrograph showing mature structures of a beta-gal+ cardiomyocyte (beta-gal precipitates, arrows), such as intercalated discs (arrowhead) and filament bands. f, g, A group of three beta-gal+ cardiomyocytes (f) were positive for cardiac troponin I (g) but negative for GFP (h). Scale bars: a, f, 25 microm; b, 20 microm; c, 10 microm; d, 5 microm; e, 1 microm.

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