FIGURE 4. BMDCs fuse with cells in the heart.
From the following article:
Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes
Manuel Alvarez-Dolado, Ricardo Pardal, Jose M. Garcia-Verdugo, John R. Fike, Hyun O. Lee, Klaus Pfeffer, Carlos Lois, Sean J. Morrison and Arturo Alvarez-Buylla
Nature 425, 968-973(30 October 2003)
doi:10.1038/nature02069

a–d, Sections at 50
m (a), 1.5
m (b, c) and electron microscopy (d) sections showing a
-gal+ cardiomyocyte in a R26R mouse transplanted with
-actin-Cre–GFP-expressing bone marrow cells. Note that
-gal+ cardiomyocytes follow the orientation of other fibres. e, Electron microscopy photomicrograph showing mature structures of a
-gal+ cardiomyocyte (
-gal precipitates, arrows), such as intercalated discs (arrowhead) and filament bands. f, g, A group of three
-gal+ cardiomyocytes (f) were positive for cardiac troponin I (g) but negative for GFP (h). Scale bars: a, f, 25
m; b, 20
m; c, 10
m; d, 5
m; e, 1
m.
