FIGURE 2. Fusion of hepatocytes with BMDCs after bone marrow transplantation.

From the following article:

Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes

Manuel Alvarez-Dolado, Ricardo Pardal, Jose M. Garcia-Verdugo, John R. Fike, Hyun O. Lee, Klaus Pfeffer, Carlos Lois, Sean J. Morrison and Arturo Alvarez-Buylla

Nature 425, 968-973(30 October 2003)

doi:10.1038/nature02069

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a, Representative image of a beta-gal+ hepatocyte detected in the liver of a R26R mouse transplanted with GFP+/Cre+ bone marrow. b, c, Semi-thin section (1.5 microm) of a beta-gal+ hepatocyte (light blue) counter-stained with toluidine blue (b), and its morphology by electron microscopy (c). The hepatocyte contains two nuclei (asterisks), a mitochondria-rich cytoplasm, and a very well developed endoplasmic reticulum typical of hepatocytes. d, High-magnification electron micrographs of a beta-gal+ hepatocyte containing glycogen storage granules, desmosomes (arrowheads) and bile canaliculi (asterisk). e, f, Ten-micrometre serial section showing a beta-gal+ hepatocyte (e) and the adjacent section (f) exhibiting GFP expression. g, h, Serial sections showing a beta-gal+ hepatocyte (g) expressing the hepatocyte-specific marker albumin in the adjacent section (h). Scale bars: a, e, 50 microm; b, 10 microm; c, 5 microm; d, 1 microm.

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