FIGURE 2. Fusion of hepatocytes with BMDCs after bone marrow transplantation.
From the following article:
Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes
Manuel Alvarez-Dolado, Ricardo Pardal, Jose M. Garcia-Verdugo, John R. Fike, Hyun O. Lee, Klaus Pfeffer, Carlos Lois, Sean J. Morrison and Arturo Alvarez-Buylla
Nature 425, 968-973(30 October 2003)
doi:10.1038/nature02069

a, Representative image of a
-gal+ hepatocyte detected in the liver of a R26R mouse transplanted with GFP+/Cre+ bone marrow. b, c, Semi-thin section (1.5
m) of a
-gal+ hepatocyte (light blue) counter-stained with toluidine blue (b), and its morphology by electron microscopy (c). The hepatocyte contains two nuclei (asterisks), a mitochondria-rich cytoplasm, and a very well developed endoplasmic reticulum typical of hepatocytes. d, High-magnification electron micrographs of a
-gal+ hepatocyte containing glycogen storage granules, desmosomes (arrowheads) and bile canaliculi (asterisk). e, f, Ten-micrometre serial section showing a
-gal+ hepatocyte (e) and the adjacent section (f) exhibiting GFP expression. g, h, Serial sections showing a
-gal+ hepatocyte (g) expressing the hepatocyte-specific marker albumin in the adjacent section (h). Scale bars: a, e, 50
m; b, 10
m; c, 5
m; d, 1
m.
