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From the following article:

Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation

Anna V. Molofsky, Ricardo Pardal, Toshihide Iwashita, In-Kyung Park, Michael F. Clarke and Sean J. Morrison

Nature 425, 962-967(30 October 2003)

doi:10.1038/nature02060

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Figure 1 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com

Figure 1

CNS stem cells and gut neural crest stem cells (NCSCs) require Bmi-1 to self-renew normally.

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Figure 2

Bmi-1 deficiency reduces proliferation but does not increase cell death in CNS stem cell colonies. P0 SVZ cells were dissociated and plated in adherent cultures, and the number of cells per colony was counted after 4, 7 and 14 d (a).

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Figure 3

p16Ink4a negatively regulates the self-renewal of CNS stem cells and gut NCSCs in culture.

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Figure 4

Restricted neural progenitors from the CNS and PNS proliferate normally in the absence of Bmi-1. E14 telencephalon cells or P0 or P30 SVZ cells were dissociated and cultured at clonal density under adherent conditions.

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