Genetically selected medicine has been much hyped but has significant potential. Regulation and treatment will depend on pharmaceutical companies more readily sharing genetic data.
doi:10.1038/425749a
Table of contents
Volume 425 Number 6960 pp749-883
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Editorials
Pharmacogenetics to come p749
New access for agriculture p749
A United Nations scheme launched last week extends unrestricted access to Nature's content within developing countries.
doi:10.1038/425749b
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News
Biosafety trials darken outlook for transgenic crops in Europe p751
Drugs bust reveals athletes' secret steroid p752
Open access wins German support p752
Fish farms' threat to salmon stocks exposed p753
Opossum hops over kangaroo to top of genome list p753
Biologists seek havens for species at risk p754
Standards-lab staff up in arms over military link p754
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News Features
Special section on human genetics: The rough guide to the genome p758
A new effort to map human genetic variation should provide a shortcut for researchers trying to uncover the roots of disease. Carina Dennis profiles the 'HapMap' project.
Carina Dennis
doi:10.1038/425758a
Special section on human genetics: With your genes? Take one of these, three times a day p760
Truly 'personalized' medicine remains a distant goal. But researchers are now thinking about how to use genomic data to avoid prescribing drugs that may kill, or won't work. Alison Abbott reports.
Alison Abbott
doi:10.1038/425760a
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Correspondence
Bioethics needs a distinct voice if it is to aid science p763
Neither scientific knowledge nor gut feeling is enough to support decision-making.
Alfons Lawen
doi:10.1038/425763a
Bioethics: role of religion cannot be ignored p763
Unnatural coverage of Chernobyl tragedy p763
India's mission to the Moon is worthwhile p763
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Books and Arts
Outstanding in his field p765
James Clerk Maxwell's work on the electromagnetic field started a revolution.
doi:10.1038/425765a
Harnessing science for Hitler p766
doi:10.1038/425766a
The eyes have it p767
doi:10.1038/425767a
Listen, learn and construct p768
doi:10.1038/425768a
Changing the world p769
doi:10.1038/425769a
An enigma for all seasons p770
doi:10.1038/425770a
A feather in the cap for bird breeders p772
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Lifelines
Vera Rubin: The observer p773
Vera Rubin, senior fellow in the Department of Terrestrial Magnetism, Carnegie Institution of Washington, is wife, parent and astronomer, in that order. She and husband Bob have four PhD offspring: two geologists, an astronomer and a mathematician.
doi:10.1038/425773a
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News and Views
ゲノミクス：7番目は6番染色体
Genomics: Six is seventh p775
The finished sequence of human chromosome 6 reveals an abundance of biological information previously buried within the draft of the human genome, and illustrates the increasing power of comparative genomics.
Jane Grimwood and Jeremy Schmutz
doi:10.1038/425775a
100 and 50 years ago p776
応用物理学：光子を捕まえるには
Applied physics: To catch a photon p777
Astronomers crave a detector sensitive enough to detect a single photon and determine its energy. A new single-pixel device can do this, and could also be built up into a large array suitable for a telescope.
Daniel E. Prober
doi:10.1038/425777a
遺伝学：豚らしい豚の秘密
Genetics: Secrets of a porkier porker p777
幹細胞：相互作用するニッチ
Stem cells: Interactive niches p778
The microenvironment, or niche, in which stem cells reside controls their renewal and maturation. The niche that regulates blood-forming stem cells in adult animals has eluded researchers — until now.
Ihor R. Lemischka and Kateri A. Moore
doi:10.1038/425778a
代謝：鍵は遺伝子にあり
Metabolism: It's in the genes p779
Warm-blooded animals of the same species, living in different climates, have different metabolic rates. In birds, this variation is not only due to physiological adaptation — it is inherent in the animals' genes.
Robert W. Furness
doi:10.1038/425779a
癌：消化器癌にヘッジホッグが関与
Cancer: A twist in a hedgehog's tale p780
The genetics of development can often explain the genesis of cancer. This now seems to be true for cancers of the gut, but the patterns of gene expression in these tumours tell a tale with a twist.
Matthew P. Scott
doi:10.1038/425780a
地球科学：山脈を成長させるには
Earth science: How do your mountains grow? p781
進化：不一致を終わらせる
Evolution: Ending incongruence p782
Recovering the true evolutionary history of any group of organisms has seemed impossible. The availability of large amounts of genomic data promises an era in which the uncertainties are better constrained.
Henry Gee
doi:10.1038/425782a
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Brief Communications
Life history: Changing sex at the same relative body size p783
Similar forces may select for gender switching across taxa in all animals with this facility.
David J. Allsop and Stuart A. West
doi:10.1038/425783a
Ancient materials: Analysis of a pharaonic embalming tar p784
Johann Koller, Ursula Baumer, Yoka Kaup, Mirjam Schmid and Ulrich Weser
doi:10.1038/425784a
First paragraph | Full Text | PDF (86K) | Supplementary information
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Articles
地球：アンデス山脈隆起の原因となりうる新生代の気候変動
Cenozoic climate change as a possible cause for the rise of the Andes p792
進化：分子系統学で生ずる不一致を解決するためのゲノム規模の手法
Genome-scale approaches to resolving incongruence in molecular phylogenies p798
Antonis Rokas, Barry L. Williams, Nicole King and Sean B. Carroll
doi:10.1038/nature02053
遺伝：ヒト6番染色体のDNA塩基配列と解析
The DNA sequence and analysis of human chromosome 6 p805
A. J. Mungall, S. A. Palmer, S. K. Sims, C. A. Edwards, J. L. Ashurst, L. Wilming, M. C. Jones, R. Horton, S. E. Hunt, C. E. Scott, J. G. R. Gilbert, M. E. Clamp, G. Bethel, S. Milne, R. Ainscough, J. P. Almeida, K. D. Ambrose, T. D. Andrews, R. I. S. Ashwell, A. K. Babbage, C. L. Bagguley, J. Bailey, R. Banerjee, D. J. Barker, K. F. Barlow, K. Bates, D. M. Beare, H. Beasley, O. Beasley, C. P. Bird, S. Blakey, S. Bray-Allen, J. Brook, A. J. Brown, J. Y. Brown, D. C. Burford, W. Burrill, J. Burton, C. Carder, N. P. Carter, J. C. Chapman, S. Y. Clark, G. Clark, C. M. Clee, S. Clegg, V. Cobley, R. E. Collier, J. E. Collins, L. K. Colman, N. R. Corby, G. J. Coville, K. M. Culley, P. Dhami, J. Davies, M. Dunn, M. E. Earthrowl, A. E. Ellington, K. A. Evans, L. Faulkner, M. D. Francis, A. Frankish, J. Frankland, L. French, P. Garner, J. Garnett, M. J. R. Ghori, L. M. Gilby, C. J. Gillson, R. J. Glithero, D. V. Grafham, M. Grant, S. Gribble, C. Griffiths, M. Griffiths, R. Hall, K. S. Halls, S. Hammond, J. L. Harley, E. A. Hart, P. D. Heath, R. Heathcott, S. J. Holmes, P. J. Howden, K. L. Howe, G. R. Howell, E. Huckle, S. J. Humphray, M. D. Humphries, A. R. Hunt, C. M. Johnson, A. A. Joy, M. Kay, S. J. Keenan, A. M. Kimberley, A. King, G. K. Laird, C. Langford, S. Lawlor, D. A. Leongamornlert, M. Leversha, C. R. Lloyd, D. M. Lloyd, J. E. Loveland, J. Lovell, S. Martin, M. Mashreghi-Mohammadi, G. L. Maslen, L. Matthews, O. T. McCann, S. J. McLaren, K. McLay, A. McMurray, M. J. F. Moore, J. C. Mullikin, D. Niblett, T. Nickerson, K. L. Novik, K. Oliver, E. K. Overton-Larty, A. Parker, R. Patel, A. V. Pearce, A. I. Peck, B. Phillimore, S. Phillips, R. W. Plumb, K. M. Porter, Y. Ramsey, S. A. Ranby, C. M. Rice, M. T. Ross, S. M. Searle, H. K. Sehra, E. Sheridan, C. D. Skuce, S. Smith, M. Smith, L. Spraggon, S. L. Squares, C. A. Steward, N. Sycamore, G. Tamlyn-Hall, J. Tester, A. J. Theaker, D. W. Thomas, A. Thorpe, A. Tracey, A. Tromans, B. Tubby, M. Wall, J. M. Wallis, A. P. West, S. S. White, S. L. Whitehead, H. Whittaker, A. Wild, D. J. Willey, T. E. Wilmer, J. M. Wood, P. W. Wray, J. C. Wyatt, L. Young, R. M. Younger, D. R. Bentley, A. Coulson, R. Durbin, T. Hubbard, J. E. Sulston, I. Dunham, J. Rogers and S. Beck
doi:10.1038/nature02055
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Letters to Nature
宇宙：炭素および酸素の存在量が低いガスからの最初の低質量星の形成
The formation of the first low-mass stars from gas with low carbon and oxygen abundances p812
物性：高転移温度超伝導体におけるコヒーレントな3次元フェルミ面
A coherent three-dimensional Fermi surface in a high-transition-temperature superconductor p814
N. E. Hussey, M. Abdel-Jawad, A. Carrington, A. P. Mackenzie and L. Balicas
doi:10.1038/nature01981
日本語要約 | Full Text | PDF (419K)
物理：大規模アレイ用に適した広帯域超伝導検出器
A broadband superconducting detector suitable for use in large arrays p817
Peter K. Day, Henry G. LeDuc, Benjamin A. Mazin, Anastasios Vayonakis and Jonas Zmuidzinas
doi:10.1038/nature02037
日本語要約 | Full Text | PDF (302K)
生物物理：生体膜モデルにおける曲率と線張力が関係しあう共存液体ドメインの画像化
Imaging coexisting fluid domains in biomembrane models coupling curvature and line tension p821
Tobias Baumgart, Samuel T. Hess and Watt W. Webb
doi:10.1038/nature02013
気候：限られた表層の流れによって作られた冷たいインドネシア通過流
Cool Indonesian throughflow as a consequence of restricted surface layer flow p824
Arnold L. Gordon, R. Dwi Susanto and Kevin Vranes
doi:10.1038/nature02038
日本語要約 | Full Text | PDF (394K)
神経：海馬錐体細胞の発火率と発火時刻の独立に行われる符号化
Independent rate and temporal coding in hippocampal pyramidal cells p828
John Huxter, Neil Burgess and John O'Keefe
doi:10.1038/nature02058
日本語要約 | Full Text | PDF (1,196K) | Supplementary information
遺伝：IGF2に生じた調節性変異はブタの筋肉成長に対する大きなQTL効果を引き起こす
A regulatory mutation in IGF2 causes a major QTL effect on muscle growth in the pig p832
Anne-Sophie Van Laere, Minh Nguyen, Martin Braunschweig, Carine Nezer, Catherine Collette, Laurence Moreau, Alan L. Archibald, Chris S. Haley, Nadine Buys, Michael Tally, Göran Andersson, Michel Georges and Leif Andersson
doi:10.1038/nature02064
医学：造血幹細胞ニッチの同定とニッチサイズの調節
Identification of the haematopoietic stem cell niche and control of the niche size p836
Jiwang Zhang, Chao Niu, Ling Ye, Haiyang Huang, Xi He, Wei-Gang Tong, Jason Ross, Jeff Haug, Teri Johnson, Jian Q. Feng, Stephen Harris, Leanne M. Wiedemann, Yuji Mishina and Linheng Li
doi:10.1038/nature02041
医学：骨芽細胞が造血幹細胞のニッチを調節する
Osteoblastic cells regulate the haematopoietic stem cell niche p841
L. M. Calvi, G. B. Adams, K. W. Weibrecht, J. M. Weber, D. P. Olson, M. C. Knight, R. P. Martin, E. Schipani, P. Divieti, F. R. Bringhurst, L. A. Milner, H. M. Kronenberg and D. T. Scadden
doi:10.1038/nature02040
医学：消化器癌の成長にはヘッジホッグリガンド刺激が広範に必要とされる
Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours p846
David M. Berman, Sunil S. Karhadkar, Anirban Maitra, Rocio Montes de Oca, Meg R. Gerstenblith, Kimberly Briggs, Antony R. Parker, Yutaka Shimada, James R. Eshleman, D. Neil Watkins and Philip A. Beachy
doi:10.1038/nature01972
医学：ヘッジホッグは膵臓癌形成の初期および後期メディエーターである
Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis p851
Sarah P. Thayer, Marina Pasca di Magliano, Patrick W. Heiser, Corinne M. Nielsen, Drucilla J. Roberts, Gregory Y. Lauwers, Yan Ping Qi, Stephan Gysin, Carlos Fernández-del Castillo, Vijay Yajnik, Bozena Antoniu, Martin McMahon, Andrew L. Warshaw and Matthias Hebrok
doi:10.1038/nature02009
細胞：Yip3はエンドソームのRab-GDI複合体の解離を触媒する
Yip3 catalyses the dissociation of endosomal Rab–GDI complexes p856
Ulf Sivars, Dikran Aivazian and Suzanne R. Pfeffer
doi:10.1038/nature02057
細胞：サイクリン依存性キナーゼCdk1の標的
Targets of the cyclin-dependent kinase Cdk1 p859
Jeffrey A. Ubersax, Erika L. Woodbury, Phuong N. Quang, Maria Paraz, Justin D. Blethrow, Kavita Shah, Kevan M. Shokat and David O. Morgan
doi:10.1038/nature02062
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Technology Features
Seeing is believing p867
Peering down an eyepiece is becoming a thing of the past. Tim Chapman takes a look into the digital world of a new generation of microscopes and imaging systems.
Tim Chapman
doi:10.1038/425867a
Lighting up the body p867
doi:10.1038/425867b
Easing the strain p869
High throughput goes 3D p871
Scanning the surface p873
table of suppliers p875
doi:10.1038/425875a
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CAREERS AND RECRUITMENT
Naturejobs
ProspectsRewarding experience p879
CAREERS AND RECRUITMENT
In search of form and function p880
Rapidly changing technology and an abundance of DNA sequences are creating more job opportunities in functional genomics — particularly for scientists who have been trained outside traditional biology. Hannah Hoag investigates.
Hannah Hoag
doi:10.1038/nj6960-880a
Building bridges p882
The costs of functional genomics can be prohibitive, and job candidates often lack the skills most researchers desire, but many academic settings are creating training schemes and unique institutes to deal with these barriers. Hannah Hoag reports.
Hannah Hoag
doi:10.1038/nj6960-882a
