Table of contents
Volume 425 Number 6958 pp545-644
Editorial
NIH at the crossroads p545
The director of the US National Institutes of Health has laid out a plan that would align the world's largest biomedical research agency more closely to the future shape of the life sciences. It deserves political support.
doi:10.1038/425545a
News
Magnetic pioneers net Nobel for putting medicine in the picture p547
Helen Pearson
doi:10.1038/425547a
Super-cool theories secure physics prize p548
Sarah Tomlin
doi:10.1038/425548a
Biologists join physics preprint club p548
Declan Butler
doi:10.1038/425548b
Scientists split over regulations on sonar use p549
Rex Dalton
doi:10.1038/425549a
European Commission dips toe into military research p549
Marika Willerroider
doi:10.1038/425549b
Spoof Nobels take researchers for a ride p550
Steve Nadis
doi:10.1038/425550a
Geologists seek to put an end to blind dates p550
Tom Clarke
doi:10.1038/425550b
Judge's sacking rocks Everglades clean-up p551
Betsy Mason
doi:10.1038/425551a
News Features
Scientific publishing: Who will pay for open access? p554
A new biology journal, positioned to compete with the likes of Nature, Science and Cell, aims to reinvent the economics of high-quality scientific publishing. Declan Butler examines the bottom line.
doi:10.1038/425554a
Think outside the sandbox p556
One grain of sand is a solid. But a lot of grains together can behave like a solid or a liquid. By probing this dual personality, physicists hope to understand a host of real-world systems, says Mark Buchanan.
doi:10.1038/425556a
Correspondence
'Open access' will not be open to everyone p559
Making authors pay for publication may not deliver the anticipated benefits.
John Ewing
doi:10.1038/425559a
Flaws undermine results of UK biotech debate p559
Scott Campbell and Ellen Townsend
doi:10.1038/425559b
Books and Arts
Mad, bad and dangerous to eat p561
What the public wants remains a mystery, but food safety can't be ignored.
Eileen Rubery reviews When Food Kills: BSE, E. coli and Disaster Science by Hugh Pennington
doi:10.1038/425561a
Prime time for mathematics p562
W. T. Gowers reviews Prime Obsession: Bernhard Riemann and the Greatest Unsolved Problem in Mathematics by John Derbyshire and The Music of the Primes: Why an Unsolved Problem in Mathematics Matters by Marcus du Sautoy
doi:10.1038/425562a
Science in culture p563
Martin Kemp reviews
doi:10.1038/425563a
Lifelines
Chris Miller: Channel hopping p564
Chris Miller is a Howard Hughes Medical Institute investigator and professor of biochemistry at Brandeis University in Waltham, Massachusetts, and works on ion-channel mechanisms.
doi:10.1038/425564a
News and Views
Neurobiology: Double trouble for neurons p565
Mutations in the presenilin protein are associated with Alzheimer's disease. It now seems that mutant presenilin could wreak havoc on neuronal functions by triggering the activation of certain genes.
Mark E. Fortini
doi:10.1038/425565a
Cosmology: The shape of the Universe p566
An analysis of astronomical data suggests not only that the Universe is finite, but also that it has a specific, rather rigid topology. If confirmed, this is a major discovery about the nature of the Universe.
George F. R. Ellis
doi:10.1038/425566a
Developmental biology: Clocking the birth of neurons p568
Different types of neurons are born in a conserved, sequential order during development. The molecular cogs in the clock-like mechanism driving this process are now being revealed.
William A. Harris
doi:10.1038/425568a
Plant biology: Locks, keys and symbioses p569
The association between legumes and nitrogen-fixing bacteria requires molecular recognition to allow bacterial entry into root hairs. The discovery of a novel type of plant receptor clarifies how this happens.
Martin Parniske and J. Allan Downie
doi:10.1038/425569a
Nuclear physics: It's a knockout p570
In collisions between nuclei, a proton or neutron might be knocked out of one nucleus. Now, two-proton knockout has been demonstrated, opening a new route to the creation of neutron-rich systems for study.
David Warner
doi:10.1038/425570a
Neuroscience: Re-recording human memories p571
Two studies help reveal the dynamics of memory. New memories that weaken during the day can be strengthened by a period of sleep. And when memories are reactivated, they must be re-stored in order to persist.
Karim Nader
doi:10.1038/425571a
100 and 50 years ago p572
doi:10.1038/425572a
News and views in brief p573
doi:10.1038/425573a
Brief Communications
Gas-bubble lesions in stranded cetaceans p575
Was sonar responsible for a spate of whale deaths after an Atlantic military exercise?
P. D. Jepson, M. Arbelo, R. Deaville, I. A. P. Patterson, P. Castro, J. R. Baker, E. Degollada, H. M. Ross, P. Herráez, A. M. Pocknell, F. Rodríguez, F. E. Howie, A. Espinosa, R. J. Reid, J. R. Jaber, V. Martin, A. A. Cunningham and A. Fernández
doi:10.1038/425575a
First paragraph | Full Text | PDF (116K)
Immunology: Hepatitis A virus link to atopic disease p576
Jennifer J. McIntire, Sarah E. Umetsu, Claudia Macaubas, Elizabeth G. Hoyte, Cengiz Cinnioglu, Luigi L. Cavalli-Sforza, Gregory S. Barsh, Joachim F. Hallmayer, Peter A. Underhill, Neil J. Risch, Gordon J. Freeman, Rosemarie H. DeKruyff and Dale T. Umetsu
doi:10.1038/425576a
First paragraph | Full Text | PDF (77K) | Supplementary information
Review
Smad-dependent and Smad-independent pathways in TGF-
family signalling p577
Rik Derynck and Ying E. Zhang
doi:10.1038/nature02006
Abstract | Full Text | PDF (558K)
Article
Plant recognition of symbiotic bacteria requires two LysM receptor-like kinases p585
Simona Radutoiu, Lene Heegaard Madsen, Esben Bjørn Madsen, Hubert H. Felle, Yosuke Umehara, Mette Grønlund, Shusei Sato, Yasukazu Nakamura, Satoshi Tabata, Niels Sandal and Jens Stougaard
doi:10.1038/nature02039
Abstract | Full Text | PDF (744K) | Supplementary information
See also: News and Views by Parniske & Downie
Letters to Nature
Dodecahedral space topology as an explanation for weak wide-angle temperature correlations in the cosmic microwave background p593
Jean-Pierre Luminet, Jeffrey R. Weeks, Alain Riazuelo, Roland Lehoucq and Jean-Philippe Uzan
doi:10.1038/nature01944
First paragraph | Full Text | PDF (419K)
See also: News and Views by Ellis
Fermi-liquid breakdown in the paramagnetic phase of a pure metal p595
N. Doiron-Leyraud, I. R. Walker, L. Taillefer, M. J. Steiner, S. R. Julian and G. G. Lonzarich
doi:10.1038/nature01968
First paragraph | Full Text | PDF (915K)
Temperature-induced valence transition and associated lattice collapse in samarium fulleride p599
J. Arvanitidis, Konstantinos Papagelis, Serena Margadonna, Kosmas Prassides and Andrew N. Fitch
doi:10.1038/nature01994
First paragraph | Full Text | PDF (330K) | Supplementary information
Understanding and tuning the epitaxy of large aromatic adsorbates by molecular design p602
M. Eremtchenko, J. A. Schaefer and F. S. Tautz
doi:10.1038/nature01901
First paragraph | Full Text | PDF (277K)
Growth of early continental crust by partial melting of eclogite p605
Robert P. Rapp, Nobumichi Shimizu and Marc D. Norman
doi:10.1038/nature02031
First paragraph | Full Text | PDF (369K)
Large Cretaceous sphenodontian from Patagonia provides insight into lepidosaur evolution in Gondwana p609
Sebastián Apesteguía and Fernando E. Novas
doi:10.1038/nature01995
First paragraph | Full Text | PDF (276K) | Supplementary information
Ultraviolet vision in a bat p612
York Winter, Jorge López and Otto von Helversen
doi:10.1038/nature01971
First paragraph | Full Text | PDF (175K)
Consolidation during sleep of perceptual learning of spoken language p614
Kimberly M. Fenn, Howard C. Nusbaum and Daniel Margoliash
doi:10.1038/nature01951
First paragraph | Full Text | PDF (139K)
See also: News and Views by Nader
Dissociable stages of human memory consolidation and reconsolidation p616
Matthew P. Walker, Tiffany Brakefield, J. Allan Hobson and Robert Stickgold
doi:10.1038/nature01930
First paragraph | Full Text | PDF (403K)
See also: News and Views by Nader
Environmentally mediated synergy between perception and behaviour in mobile robots p620
Paul F. M. J. Verschure, Thomas Voegtlin and Rodney J. Douglas
doi:10.1038/nature02024
First paragraph | Full Text | PDF (347K) | Supplementary information
Regulation of neuroblast competence in Drosophila p624
Bret J. Pearson and Chris Q. Doe
doi:10.1038/nature01910
First paragraph | Full Text | PDF (717K) | Supplementary information
See also: News and Views by Harris
Basal body dysfunction is a likely cause of pleiotropic Bardet–Biedl syndrome p628
Stephen J. Ansley, Jose L. Badano, Oliver E. Blacque, Josephine Hill, Bethan E. Hoskins, Carmen C. Leitch, Jun Chul Kim, Alison J. Ross, Erica R. Eichers, Tanya M. Teslovich, Allan K. Mah, Robert C. Johnsen, John C. Cavender, Richard Alan Lewis, Michel R. Leroux, Philip L. Beales and Nicholas Katsanis
doi:10.1038/nature02030
First paragraph | Full Text | PDF (728K) | Supplementary information
The Wnt/-catenin pathway regulates cardiac valve formation p633
Adam F. L. Hurlstone, Anna-Pavlina G. Haramis, Erno Wienholds, Harry Begthel, Jeroen Korving, Fredericus van Eeden, Edwin Cuppen, Danica Zivkovic, Ronald H. A. Plasterk and Hans Clevers
doi:10.1038/nature02028
First paragraph | Full Text | PDF (451K) | Supplementary information
A receptor kinase gene of the LysM type is involved in legumeperception of rhizobial signals p637
Esben Bjørn Madsen, Lene Heegaard Madsen, Simona Radutoiu, Magdalena Olbryt, Magdalena Rakwalska, Krzysztof Szczyglowski, Shusei Sato, Takakazu Kaneko, Satoshi Tabata, Niels Sandal and Jens Stougaard
doi:10.1038/nature02045
First paragraph | Full Text | PDF (492K) | Supplementary information
See also: News and Views by Parniske & Downie
New on the Market
Take a closer look p641
Light, stereo, scanning, transmission and other angles on microscopy.
doi:10.1038/425641a
Naturejobs
ProspectsNew perspectives p643
Paul Smaglik
doi:10.1038/nj6958-643a
Career View
Young Scientist: Italian biotechnologists organize p644
Francesco Lescai and Marco Quarta
doi:10.1038/nj6958-644a
Nuts & Bolts p644
Deb Koen
doi:10.1038/nj6958-644b
Movers p644
doi:10.1038/nj6958-644c
