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Nature 425, 565-566 (9 October 2003) | doi:10.1038/425565a
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Chair, Department of Informatic Medicine and Personalized Health
- University of Missouri-Kansas City
- Kansas City, Missouri, USA
Assistant Manager-Pharma / CRO-Global Strategic Sourcing
- Varda Biotech
- Mumbai India
Neurobiology: Double trouble for neurons
Mark E. Fortini1
Abstract
Mutations in the presenilin protein are associated with Alzheimer's disease. It now seems that mutant presenilin could wreak havoc on neuronal functions by triggering the activation of certain genes.
Working in Frankfurt, Germany, in 1901, Alois Alzheimer encountered a middle-aged patient named Auguste D. suffering from confusion and memory loss1.
- Mark E. Fortini is in the Laboratory of Protein Dynamics and Signalling, National Cancer Institute, 1050 Boyles Street, Frederick, Maryland 21702, USA.
Email: fortini@ncifcrf.gov
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