Table of contents
Volume 425 Number 6957 pp435-543
Editorial
In praise of Gates p435
The co-founder of Microsoft has made a mint from a business that many attack, but his efforts in Africa highlight a virtue: a philanthropic understanding of science. The world needs more of it.
doi:10.1038/425435a
News
Mosquito production mooted as fast track to malaria vaccine p437
Declan Butler
doi:10.1038/425437a
China plays cards close to its chest over manned space shot p438
David Cyranoski
doi:10.1038/425438a
NIH 'roadmap' charts course to tackle big research issues p438
Erika Check
doi:10.1038/425438b
Ion-powered probe set for year-long Moon trek p438
Geoff Brumfiel
doi:10.1038/425438c
Harvard heralds fresh take on systems biology p439
Erika Check
doi:10.1038/425439a
Adviser gears up to bring scientists to matters of state p439
Geoff Brumfiel
doi:10.1038/425439b
Research council plan for Europe gets up steam p440
Alison Abbott
doi:10.1038/425440a
Wellcome to fund publication in open-access journals p440
Declan Butler
doi:10.1038/425440b
China takes centre stage for liver proteome p441
David Cyranoski
doi:10.1038/425441a
Planck makes permanent posts p441
Quirin Schiermeier
doi:10.1038/425441b
News Feature
Across the great divide p444
Scientists like to think that research collaboration can overcome political barriers. But for those on opposite sides of the Israeli–Palestinian conflict, how realistic is this ideal? Jim Giles visited the region to find out.
doi:10.1038/425444a
Correspondence
Outline for a European Research Council p451
The ERC should start small and from scratch, using the expertise of existing bodies.
Carol Featherstone and Kai Simons
doi:10.1038/425451a
How scientists can help to protect US homeland p451
Charles E. McQueary
doi:10.1038/425451b
Books and Arts
A magical history tour p453
Take a trip to the end of the ice age with a fictional guide.
Robert L. Bettinger reviews After the Ice: A Global Human History 20,000–5000 BC by Steven Mithen
doi:10.1038/425453a
Thinking of apes p454
Andrew Whiten reviews Intelligence of Apes and Other Rational Beings by Duane M. Rumbaugh and David A. Washburn
doi:10.1038/425454a
The cry of the food critic p454
Mark Woolhouse reviews Don't Worry [It's Safe to Eat]. The True Story of GM Food, BSE and Foot and Mouth by Andrew Rowell
doi:10.1038/425454b
Exhibition: A hobbit-forming show p455
Henry Gee
doi:10.1038/425455a
News and Views
Sedimentology: Floods of record p459
Research on two Bolivian rivers provides explanations of how and when they flood. It also gives pointers for interpreting Earth's history as recorded by the sediments left behind by flood waters.
Chris Paola
doi:10.1038/425459a
Immunology: Dangerous liaisons p460
Alerting the immune system to invading microorganisms is essential for effective immunity. Uric acid released by damaged cells is a danger signal that is able to notify immune cells of microbial attack.
William R. Heath and Francis R. Carbone
doi:10.1038/425460a
Developmental biology: Twisting the body into shape p461
Molecular signals are not the only forces that pattern and shape the developing embryo. Mechanical stresses sensed by cells also seem to be involved in creating the body plan.
Ian C. Scott and Didier Y. R. Stainier
doi:10.1038/425461a
Chemistry: Mirrors in Flatland p463
Many molecules exist in two mirror-image forms, which have different biological properties. A new way of creating solid chiral surfaces might make it easier to synthesize and purify only one of the mirror forms.
Rasmita Raval
doi:10.1038/425463a
Neurobiology: Backchat at the synapse p464
At synapses, nerve cells release neurotransmitters, which affect other nerve cells or muscles. Studies of how muscles in turn influence neurotransmitter release hint at how synapses adapt to changes in use.
Patricia C. Salinas
doi:10.1038/425464a
Materials science: Molecules squeezed and stroked p467
Soft matter is often found in tight spots. A study shows that tangled chain-like molecules, squeezed between solid surfaces and stroked by sliding, might become exceptionally ordered.
Steve Granick, Zhiqun Lin and Sung Chul Bae
doi:10.1038/425467a
Developmental biology: Partners united p468
There is often more than one way of cracking a scientific problem. Two views of one question have led to the marriage of two signalling proteins in search of a partner.
Matthew Freeman
doi:10.1038/425468a
Cell biology: The hippo hypothesis p469
The perfection of a fly's eye and the chaotic nature of tumours provide eloquent examples of the need to coordinate cell death and proliferation. The intricacies of the underlying mechanism are now being uncovered.
Michael E. Rothenberg and Yuh-Nung Jan
doi:10.1038/425469a
100 and 50 years ago p469
doi:10.1038/425469b
Obituary: Patricia S. Goldman-Rakic (1937–2003) p471
Eric J. Nestler
doi:10.1038/425471a
News and views in brief p472
doi:10.1038/425472a
Brief Communications
Animal Welfare: Captivity effects on wide-ranging carnivores p473
Animals that roam over a large territory in the wild do not take kindly to being confined.
Ros Clubb and Georgia Mason
doi:10.1038/425473a
First paragraph | Full Text | PDF (103K)
Explosives: A microsensor for trinitrotoluene vapour p474
L. A. Pinnaduwage, A. Gehl, D. L. Hedden, G. Muralidharan, T. Thundat, R. T. Lareau, T. Sulchek, L. Manning, B. Rogers, M. Jones and J. D. Adams
doi:10.1038/425474a
First paragraph | Full Text | PDF (77K)
Hypothesis
Binary switches and modification cassettes in histone biology and beyond p475
Wolfgang Fischle, Yanming Wang and C. David Allis
doi:10.1038/nature02017
Abstract | Full Text | PDF (348K)
Article
Evolution of complex life cycles in helminth parasites p480
Geoff A. Parker, Jimmy C. Chubb, Michael A. Ball and Guy N. Roberts
doi:10.1038/nature02012
Abstract | Full Text | PDF (215K)
Letters to Nature
Programmable computing with a single magnetoresistive element p485
A. Ney, C. Pampuch, R. Koch and K. H. Ploog
doi:10.1038/nature02014
First paragraph | Full Text | PDF (232K)
Controlling anisotropic nanoparticle growth through plasmon excitation p487
Rongchao Jin, Y. Charles Cao, Encai Hao, Gabriella S. Métraux, George C. Schatz and Chad A. Mirkin
doi:10.1038/nature02020
First paragraph | Full Text | PDF (561K) | Supplementary information
Enantiospecific electrodeposition of a chiral catalyst p490
Jay A. Switzer, Hiten M. Kothari, Philippe Poizot, Shuji Nakanishi and Eric W. Bohannan
doi:10.1038/nature01990
First paragraph | Full Text | PDF (437K)
See also: News and Views by Raval
Episodic sediment accumulation on Amazonian flood plains influenced by El Niño/Southern Oscillation p493
Rolf Aalto, Laurence Maurice-Bourgoin, Thomas Dunne, David R. Montgomery, Charles A. Nittrouer and Jean-Loup Guyot
doi:10.1038/nature02002
First paragraph | Full Text | PDF (1,543K)
See also: News and Views by Paola
Boundary-layer mantle flow under the Dead Sea transform fault inferred from seismic anisotropy p497
Georg Rümpker, Trond Ryberg, Günter Bock and Desert Seismology Group
doi:10.1038/nature01982
First paragraph | Full Text | PDF (455K) | Supplementary information
The oldest articulated chondrichthyan from the Early Devonian period p501
Randall F. Miller, Richard Cloutier and Susan Turner
doi:10.1038/nature02001
First paragraph | Full Text | PDF (1,146K)
Temperature excludes N2-fixing heterocystous cyanobacteria in the tropical oceans p504
Marc Staal, Filip J. R. Meysman and Lucas J. Stal
doi:10.1038/nature01999
First paragraph | Full Text | PDF (217K) | Supplementary information
Jelly belly protein activates the receptor tyrosine kinase Alk to specify visceral muscle pioneers p507
Hsiu-Hsiang Lee, Audra Norris, Joseph B. Weiss and Manfred Frasch
doi:10.1038/nature01916
First paragraph | Full Text | PDF (1,443K) | Supplementary information
See also: News and Views by Freeman
Jeb signals through the Alk receptor tyrosine kinase to drive visceral muscle fusion p512
Camilla Englund, Christina E. Lorén, Caroline Grabbe, Gaurav K. Varshney, Fabienne Deleuil, Bengt Hallberg and Ruth H. Palmer
doi:10.1038/nature01950
First paragraph | Full Text | PDF (1,799K) | Supplementary information
See also: News and Views by Freeman
Molecular identification of a danger signal that alerts the immune system to dying cells p516
Yan Shi, James E. Evans and Kenneth L. Rock
doi:10.1038/nature01991
First paragraph | Full Text | PDF (842K) | Supplementary information
See also: News and Views by Heath & Carbone
Differential regulation of EIN3 stability by glucose and ethylene signalling in plants p521
Shuichi Yanagisawa, Sang-Dong Yoo and Jen Sheen
doi:10.1038/nature01984
First paragraph | Full Text | PDF (386K)
Role of visual pigment properties in rod and cone phototransduction p526
Vladimir Kefalov, Yingbin Fu, Nicholas Marsh-Armstrong and King-Wai Yau
doi:10.1038/nature01992
First paragraph | Full Text | PDF (1,136K) | Supplementary information
Haem can bind to and inhibit mammalian calcium-dependent Slo1 BK channels p531
Xiang Dong Tang, Rong Xu, Mark F. Reynolds, Maria L. Garcia, Stefan H. Heinemann and Toshinori Hoshi
doi:10.1038/nature02003
First paragraph | Full Text | PDF (494K) | Supplementary information
Staphylocoagulase is a prototype for the mechanism of cofactor-induced zymogen activation p535
Rainer Friedrich, Peter Panizzi, Pablo Fuentes-Prior, Klaus Richter, Ingrid Verhamme, Patricia J. Anderson, Shun-Ichiro Kawabata, Robert Huber, Wolfram Bode and Paul E. Bock
doi:10.1038/nature01962
First paragraph | Full Text | PDF (856K) | Supplementary information
New on the Market
Codon optimization to PCR p540
Recent introductions include an array of heart disease genes.
doi:10.1038/425540a
Naturejobs
ProspectsPhysics temps p541
Paul Smaglik
doi:10.1038/nj6957-541a
POSTDOCS
Going multidisciplinary p542
A varied training path is trickier to navigate than traditional specialized routes — but can be more rewarding, says Myrna Watanabe
Myrna Watanabe
doi:10.1038/nj6957-542a
