Access
To read this story in full you will need to login or make a payment (see right).
News and Views
Nature 425, 469-470 (2 October 2003) | doi:10.1038/425469a
Open Innovation Challenges
-
Methods of Modeling Adaptation in Populations
The analysis of adaptation with a population is a frequently encountered computational modeling scen...
-
Optimizing Sub-cellular Localization Tags
The Seeker is looking for methods to optimize sub-cellular localization tags for protein expression....
- More Challenges
- Powered by:
nature jobs
Senior Computational Scientist
- Argonne National Laboratory
- Argonne, IL, United States
Scientist / Sr. Scientist - Biopharmaceutics
- Syngene International
- Bangalore, Karnataka 560099 India
Cell biology: The hippo hypothesis
Michael E. Rothenberg1 & Yuh-Nung Jan1
Abstract
The perfection of a fly's eye and the chaotic nature of tumours provide eloquent examples of the need to coordinate cell death and proliferation. The intricacies of the underlying mechanism are now being uncovered.
Just as the number of working parts in a machine is crucial, so too is the number of cells in a tissue. This means that the creation of new cells (by proliferation) and the elimination of excess ones (by programmed cell death, or 'apoptosis') must be tightly coordinated.
- Departments of Physiology and Biochemistry, Howard Hughes Medical Institute, University of California, San Francisco, California 94143-0725, USA.
Correspondence to: Yuh-Nung Jan1 Email: ynjan@itsa.ucsf.edu
To read this story in full you will need to login or make a payment (see right).
