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Nature 425, 407-410 (25 September 2003) | doi:10.1038/nature01913;
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A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors
Heat shock protein 90 (Hsp90) is a molecular chaperone that plays a key role in the conformational maturation of oncogenic signalling proteins, including HER-2/ErbB2, Akt, Raf-1, Bcr-Abl and mutated p53. Hsp90 inhibitors bind to Hsp90, and induce the proteasomal degradation of Hsp90 client proteins.
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