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Editorial

Dealing with democracy p329

The drive for greater public participation in the regulation and politics of technologies is both necessary and irreversible. But proposals to extend it into the selection of publicly funded research contain dangers to science and society.

doi:10.1038/425329a


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News

Gates steps up war on malaria with donation of $168 million p331

Declan Butler

doi:10.1038/425331a


UK public opposes government on transgenic crops p331

Jim Giles

doi:10.1038/425331b


Report raises hopes for grand network of US ecology centres p332

Rex Dalton

doi:10.1038/425332a


Vaccine claim lifts company's stock but angers researchers p332

Erika Check

doi:10.1038/425332b


SARS triggers biomedical shake-up in China p333

David Cyranoski

doi:10.1038/425333a


Secret garden opens up to public p333

David Cyranoski

doi:10.1038/425333b


Open-access row leads paper to shed authors p334

Declan Butler

doi:10.1038/425334a


Cosmologists cluster to plot course towards dark energy p335

Geoff Brumfiel

doi:10.1038/425335a


DNA lab welcomes Dalai Lama to Tibetan science community p335

Erika Check

doi:10.1038/425335b


News in brief p336

doi:10.1038/425336a


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News

Correction p337

doi:10.1038/425337a


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News Features

Alaska's climate: Too hot to handle p338

Alaska is warming up more than anywhere else on Earth. Climate researchers are now turning to regional models to find out why — and how to deal with it. John Whitfield went north to investigate.

doi:10.1038/425338a


Dyslexia: Lost for words p340

Thanks in part to brain-imaging technology, researchers are now homing in on the root cause of dyslexia. But research into strategies for treating the condition is still in its infancy, says Glenn Murphy.

doi:10.1038/425340a


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Correspondence

Global project needed to tackle coffee crisis p343

A sharp drop in coffee prices has caused widespread suffering and hindered research.

Fernando E. Vega, Eric Rosenquist and Wanda Collins

doi:10.1038/425343a


The public has its own view of what is a risk p343

Emmanuelle Schuler

doi:10.1038/425343b


Feynman put a personal spin on physics p343

R. W. D. Nickalls

doi:10.1038/425343c


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Books and Arts

Learning to evolve p345

A fresh look at whether learning alters the course of natural selection.

Kevin N. Laland reviews Evolution and Learning: The Baldwin Effect Reconsidered

doi:10.1038/425345a


Biologists become clock-watchers p346

John Palmer reviews Chronobiology: Biological Timekeeping

doi:10.1038/425346a


A dangerous world? p346

Roger Cox reviews The Suffering Gene: Environmental Threats to our Health by Roy Burdon

doi:10.1038/425346b


Exhibition: Unnatural causes p347

Alison Abbott

doi:10.1038/425347a


Reissued classics p347

doi:10.1038/425347b


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Lifelines

Roberto Macchiarelli: The whole tooth p349

Roberto Macchiarelli is a palaeoanthropologist. Until recently at the National Museum of Prehistory and Ethnography in Rome, he is currently professor of human palaeontology at the University of Poitiers, France.

doi:10.1038/425349a


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News and Views

Immunology: Professional secrets p351

Looking inside the compartments of certain immune cells — professional antigen-presenting cells — has revealed how the immune system can trigger a cell-killing response to extracellular pathogens.

Craig R. Roy

doi:10.1038/425351a


Plasma physics: Cosmic waves in the lab p352

An Alfvén-wave maser, a feature of atmospheric and astrophysical science, has been created in a laboratory, and opens the way for further Earth-bound investigations of cosmic phenomena.

Rod Boswell

doi:10.1038/425352a


Stem cells: To be and not to be p353

It has long been proposed that stem cells function by dividing to generate an identical daughter cell and a cell that becomes more specialized. New work illustrates such asymmetric division and its molecular basis.

Haifan Lin

doi:10.1038/425353a


100 and 50 years ago p356

doi:10.1038/425356a


Synthetic chemistry: Ship reverses out of bottle p356

The industrial application of zeolites is limited by the cost of certain organic materials that are needed to make them, but which are destroyed in the process. A clever technique offers a solution.

Avelino Corma

doi:10.1038/425356b


Cancer: The rules of attraction p357

The puzzle of how a drug that binds to a protein found in normal cells as well as cancer cells preferentially kills tumours is now solved — the target protein exists in a drug-binding complex in tumour cells.

Len Neckers and Yong-Sok Lee

doi:10.1038/425357a


Applied physics: Spintronics gets a magnetic flute p359

Magnetic-memory devices of the future could be based on 'spintronics', through switching the directions of electron spins. New work confirms the physics behind a spin-switching mechanism.

Jonathan Sun

doi:10.1038/425359a


Zoology: Light touch on the rudder p360

Tim Lincoln

doi:10.1038/425360a


Plant biology: Water gate p361

Flooding reduces the ability of roots to absorb water. The molecular basis for this paradox involves the regulation of water-channel proteins by the pH inside root cells.

N. Michele Holbrook and Maciej A. Zwieniecki

doi:10.1038/425361a


Obituary: Edward Teller (1908–2003) p362

John Maddox

doi:10.1038/425362a


News and views in brief p364

doi:10.1038/425364a


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Brief Communications

Oceanography: Anthropogenic carbon and ocean pH p365

The coming centuries may see more ocean acidification than the past 300 million years.

Ken Caldeira and Michael E. Wickett

doi:10.1038/425365a


Archaeology: Sharp shift in diet at onset of Neolithic p366

Michael P. Richards, Rick J. Schulting and Robert E. M. Hedges

doi:10.1038/425366a


Corrigendum: Insecticide resistance in mosquito vectors p366

doi:10.1038/425366b


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Article

Bending-related faulting and mantle serpentinization at the Middle America trench p367

C. R. Ranero, J. Phipps Morgan, K. McIntosh and C. Reichert

doi:10.1038/nature01961


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Letters to Nature

A test of general relativity using radio links with the Cassini spacecraft p374

B. Bertotti, L. Iess and P. Tortora

doi:10.1038/nature01997


Uniform resonant chaotic mixing in fluid flows p376

T. H. Solomon and Igor Mezic acute

doi:10.1038/nature01993


Microwave oscillations of a nanomagnet driven by a spin-polarized current p380

S. I. Kiselev, J. C. Sankey, I. N. Krivorotov, N. C. Emley, R. J. Schoelkopf, R. A. Buhrman and D. C. Ralph

doi:10.1038/nature01967

See also: News and Views by Sun


Video-speed electronic paper based on electrowetting p383

Robert A. Hayes and B. J. Feenstra

doi:10.1038/nature01988


A combustion-free methodology for synthesizing zeolites and zeolite-like materials p385

Hyunjoo Lee, Stacey I. Zones and Mark E. Davis

doi:10.1038/nature01980

See also: News and Views by Corma


An Arctic mammal fauna from the Early Pliocene of North America p388

Richard H. Tedford and C. Richard Harington

doi:10.1038/nature01892


Volunteering leads to rock–paper–scissors dynamics in a public goods game p390

Dirk Semmann, Hans-Jürgen Krambeck and Manfred Milinski

doi:10.1038/nature01986


Cytosolic pH regulates root water transport during anoxic stress through gating of aquaporins p393

Colette Tournaire-Roux, Moira Sutka, Hélène Javot, Elisabeth Gout, Patricia Gerbeau, Doan-Trung Luu, Richard Bligny and Christophe Maurel

doi:10.1038/nature01853

See also: News and Views by Holbrook & Zwieniecki


ER–phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cells p397

Pierre Guermonprez, Loredana Saveanu, Monique Kleijmeer, Jean Davoust, Peter van Endert and Sebastian Amigorena

doi:10.1038/nature01911


Phagosomes are competent organelles for antigen cross-presentation p402

Mathieu Houde, Sylvie Bertholet, Etienne Gagnon, Sylvain Brunet, Guillaume Goyette, Annie Laplante, Michael F. Princiotta, Pierre Thibault, David Sacks and Michel Desjardins

doi:10.1038/nature01912

See also: News and Views by Roy


A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors p407

Adeela Kamal, Lia Thao, John Sensintaffar, Lin Zhang, Marcus F. Boehm, Lawrence C. Fritz and Francis J. Burrows

doi:10.1038/nature01913

See also: News and Views by Neckers & Lee


A micrococcal nuclease homologue in RNAi effector complexes p411

Amy A. Caudy, René F. Ketting, Scott M. Hammond, Ahmet M. Denli, Anja M. P. Bathoorn, Bastiaan B. J. Tops, Jose M. Silva, Mike M. Myers, Gregory J. Hannon and Ronald H. A. Plasterk

doi:10.1038/nature01956


The nuclear RNase III Drosha initiates microRNA processing p415

Yoontae Lee, Chiyoung Ahn, Jinju Han, Hyounjeong Choi, Jaekwang Kim, Jeongbin Yim, Junho Lee, Patrick Provost, Olof Rådmark, Sunyoung Kim and V. Narry Kim

doi:10.1038/nature01957


A structural state of the myosin V motor without bound nucleotide p419

Pierre-Damien Coureux, Amber L. Wells, Julie Ménétrey, Christopher M. Yengo, Carl A. Morris, H. Lee Sweeney and Anne Houdusse

doi:10.1038/nature01927


Electron cryo-microscopy shows how strong binding of myosin to actin releases nucleotide p423

Kenneth C. Holmes, Isabel Angert, F. Jon Kull, Werner Jahn and Rasmus R. Schröder

doi:10.1038/nature02005


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Naturejobs

Prospects

True grit p429

Paul Smaglik

doi:10.1038/nj6956-429a


REGIONS

Northern England: Rising star p430

Paul Smaglik

doi:10.1038/nj6956-430a


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