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Nature 425, 357-359 (25 September 2003) | doi:10.1038/425357a
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Protect Enzyme from In Planta Degradation
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Sensory Scientist
- Philip Morris International (PMI)
- Neuchatel, Switzerland
Team Leader for Analytical Development
- Novo Nordisk
- Bagsværd, Denmark
Cancer: The rules of attraction
Abstract
The puzzle of how a drug that binds to a protein found in normal cells as well as cancer cells preferentially kills tumours is now solved — the target protein exists in a drug-binding complex in tumour cells.
Targeting a specific protein or a single signalling pathway that is required for the survival of tumour cells but not normal cells would seem to be a promising anticancer strategy. Unfortunately, few such unique targets exist, and it is becoming clear that inhibiting a single pathway might not be enough to tackle cancers that result from several genetic abnormalities.
- Len Neckers is in the Urologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
- Yong-Sok Lee is in the Center for Molecular Modelling, Center for Information Technology, National Institutes of Health, Bethesda, Maryland 20892, USA.
Correspondence to: Len Neckers1 Email: len@helix.nih.gov
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