FIGURE 4. CXCR4 expression in human renal cell carcinoma.
From the following article:
Chemokine receptor CXCR4 downregulated by von Hippel–Lindau tumour suppressor pVHL
Peter Staller, Jitka Sulitkova, Joanna Lisztwan, Holger Moch, Edward J. Oakeley and Wilhelm Krek
Nature 425, 307-311(18 September 2003)
doi:10.1038/nature01874
a, Quantitative reverse transcriptase PCR analysis of normal kidney tissues and renal cell carcinoma. Fold expression levels are normalized to 18S rRNA and compared with the average values in normal kidneys. Red bars, CXCR4; blue bars, GLUT1; green bars, CA9. b–g, Immunohistochemical evaluation of CXCR4 expression. b, Invasive breast cancer. c, Normal renal tissue; arrows indicate a glomerulum (left) and a tubulus (right). Lymphocellular infiltrates stain intensively. Examples of weak (d) and strong (e–g) CXCR4 expression in clear cell RCCs. Original magnifications: b, c, 
400; d, e, 50; f, g, 400. h, Kaplan–Meier analysis of tumour-specific survival in patients with clear cell RCC according to CXCR4 expression. P = 0.001.
