Editorial

Honesty and denial at NASA p1

The world's leading space agency is suffering not only from managerial dysfunction, but also from a failure to address strategic issues. NASA and its stakeholders need to face up to the challenges ahead.

doi:10.1038/425001a

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News

Experts fear network paralysis as computer worms blast Internet p3

Declan Butler

doi:10.1038/425003a

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Retraction ends furore over cancer vaccine p4

Alison Abbott

doi:10.1038/425004a

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Columbia inquiry prompts White House strategy review p4

Tony Reichhardt

doi:10.1038/425004b

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Peers rally in support of accused scientist p5

Erika Check

doi:10.1038/425005a

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Court ruling sounds note of caution for sonar system p6

Rex Dalton

doi:10.1038/425006a

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Statistical model leaves Peru counting the cost of civil war p6

Jonathan Knight

doi:10.1038/425006b

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Lion man takes pride of place as oldest statue p7

Rex Dalton

doi:10.1038/425007a

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Britain set to pull plug on nuclear-fuel reprocessing p7

Quirin Schiermeier

doi:10.1038/425007b

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News in brief p8

doi:10.1038/425008a

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News

Correction p9

doi:10.1038/425009a

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News Features

Gene regulation: RNA to the rescue? p10

Disease therapies based on a technique for gene silencing called RNA interference are racing towards the clinic. Erika Check investigates molecular medicine's next big thing.

doi:10.1038/425010a

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Hot tempers, hard core p13

Were the last dinosaurs wiped out when interplanetary debris hit what is now the coast of Mexico? A drilling project that promised answers has been plagued by squabbles over access to samples. Rex Dalton reports.

doi:10.1038/425013a

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Correspondence

Breeding to tackle blight without copper or GM p15

Gene mapping can help conventional breeders to focus efforts on building resistance.

James M. Duncan

doi:10.1038/425015a

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Despite Franklin's work, Wilkins earned his Nobel p15

Doris T. Zallen

doi:10.1038/425015b

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Books and Arts

Learning to teach p17

Can studies of how people learn be put to use in the classroom?

Peter Bryant reviews Original Intelligence: Unlocking the Mystery of Who We Are by David and Ann Premack

doi:10.1038/425017a

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Troubled waters p18

Keith Thomson reviews FitzRoy: The Remarkable Story of Darwin's Captain and the Invention of the Weather Forecast by John and Mary Gribbin and Evolution's Captain: The Tragic Fate of Robert FitzRoy, the Man who Sailed Charles Darwin Around the World by Peter Nichols

doi:10.1038/425018a

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The universal engineer p18

Julio M. Ottino reviews Discussion of the Method: Conducting the Engineer's Approach to Problem Solving by Billy Vaughn Koen

doi:10.1038/425018b

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Sculpture: Breaking with tradition p19

Alison Abbott

doi:10.1038/425019a

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concepts

Cell plasticity: Flexible arrangement p21

Neil D. Theise and Ian Wilmut

doi:10.1038/425021a

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News and Views

Palaeoanthropology: Tracking the first Americans p23

A study of 33 ancient skulls excavated from Mexico invites us to reconsider our view of the ancestry of the early Americans. Unlike most other early American remains, the skulls resemble those from south Asian populations.

Tom D. Dillehay

doi:10.1038/425023a

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Earth science: Just add water p24

A new model could explain why Earth's upper mantle is depleted of many trace elements. At a certain depth, minerals might release water, creating a molten filter that traps trace elements in the mantle beneath.

Albrecht W. Hofmann

doi:10.1038/425024a

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Cell biology: Join the crowd p27

Cells are packed with large molecules. The ramifications of this 'crowding' for a wide range of intracellular processes are only now becoming more generally understood.

R. John Ellis and Allen P. Minton

doi:10.1038/425027a

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Quantum physics: Entanglement hits the big time p28

Entanglement is a quantum phenomenon usually associated with the microscopic world. Now it is clear that its effects are also relevant on macroscopic scales, such as in the magnetic properties of some solids.

Vlatko Vedral

doi:10.1038/425028a

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Genetics: A balancing act p29

Mutations in model organisms are grist to the geneticists' mill: they help in assigning function to genes. Chromosome engineering in mice makes it easier to pinpoint the location of randomly induced mutations.

Janet Rossant

doi:10.1038/425029a

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100 and 50 years ago p31

doi:10.1038/425031a

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Climate change: Chilled out in the ice-age Atlantic p32

A new reconstruction of temperatures in the Atlantic Ocean during the last ice age, 21,000 years ago, is the latest act in providing climate modellers with details of the past to help predict the future.

Alan C. Mix

doi:10.1038/425032a

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Reproductive biology: Forming an attachment p33

Clare Thomas

doi:10.1038/425033a

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News and views in brief p34

doi:10.1038/425034a

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Brief Communications

Prion disease: Horizontal prion transmission in mule deer p35

The gathering of deer during winter may foster the spread of chronic wasting disease.

Michael W. Miller and Elizabeth S. Williams

doi:10.1038/425035a

First paragraph | Full Text | PDF (126K)

Nanotube electronics: Large-scale assembly of carbon nanotubes p36

Saleem G. Rao, Ling Huang, Wahyu Setyawan and Seunghun Hong

doi:10.1038/425036a

First paragraph | Full Text | PDF (144K) | Supplementary information

Innate defence: Evidence for memory in invertebrate immunity p37

Joachim Kurtz and Karoline Franz

doi:10.1038/425037a

First paragraph | Full Text | PDF (122K)

Microfluidic systems: High radial acceleration in microvortices p38

J. Patrick Shelby, David S.W. Lim, Jason S. Kuo and Daniel T. Chiu

doi:10.1038/425038a

First paragraph | Full Text | PDF (61K) | Supplementary information

Hypothesis

Whole-mantle convection and the transition-zone water filter p39

David Bercovici and Shun-ichiro Karato

doi:10.1038/nature01918

Abstract | Full Text | PDF (199K) | Supplementary information

See also: News and Views by Hofmann

Letters to Nature

Violation of a Bell-like inequality in single-neutron interferometry p45

Yuji Hasegawa, Rudolf Loidl, Gerald Badurek, Matthias Baron and Helmut Rauch

doi:10.1038/nature01881

First paragraph | Full Text | PDF (327K)

Entangled quantum state of magnetic dipoles p48

S. Ghosh, T. F. Rosenbaum, G. Aeppli and S. N. Coppersmith

doi:10.1038/nature01888

First paragraph | Full Text | PDF (236K)

See also: News and Views by Vedral

Magnetic enhancement of superconductivity from electron spin domains p51

H. A. Radovan, N. A. Fortune, T. P. Murphy, S. T. Hannahs, E. C. Palm, S. W. Tozer and D. Hall

doi:10.1038/nature01842

First paragraph | Full Text | PDF (417K) | Supplementary information

Geochemical evidence for efficient aquifer isolation over geological timeframes p55

Bernard Marty, Sarah Dewonck and Christian France-Lanord

doi:10.1038/nature01966

First paragraph | Full Text | PDF (383K)

Laboratory models of the thermal evolution of the mantle during rollback subduction p58

C. Kincaid and R. W. Griffiths

doi:10.1038/nature01923

First paragraph | Full Text | PDF (456K)

Craniometric evidence for Palaeoamerican survival in Baja California p62

Rolando González-José, Antonio González-Martín, Miquel Hernández, Héctor M. Pucciarelli, Marina Sardi, Alfonso Rosales and Silvina Van der Molen

doi:10.1038/nature01816

First paragraph | Full Text | PDF (520K) | Supplementary information

See also: News and Views by Dillehay

A uniquely specialized ear in a very early tetrapod p65

J. A. Clack, P. E. Ahlberg, S. M. Finney, P. Dominguez Alonso, J. Robinson and R. A. Ketcham

doi:10.1038/nature01904

First paragraph | Full Text | PDF (486K) | Supplementary information

Ecological and genetic spatial structuring in the Canadian lynx p69

Eli Knispel Rueness, Nils Chr. Stenseth, Mark O'Donoghue, Stan Boutin, Hans Ellegren and Kjetill S. Jakobsen

doi:10.1038/nature01942

First paragraph | Full Text | PDF (493K) | Supplementary information

Evolution of cooperation and conflict in experimental bacterial populations p72

Paul B. Rainey and Katrina Rainey

doi:10.1038/nature01906

First paragraph | Full Text | PDF (189K)

Evolution of novel cooperative swarming in the bacterium Myxococcus xanthus p75

Gregory J. Velicer and Yuen-tsu N. Yu

doi:10.1038/nature01908

First paragraph | Full Text | PDF (289K)

Host sanctions and the legume–rhizobium mutualism p78

E. Toby Kiers, Robert A. Rousseau, Stuart A. West and R. Ford Denison

doi:10.1038/nature01931

First paragraph | Full Text | PDF (236K)

Functional genetic analysis of mouse chromosome 11 p81

Benjamin T. Kile, Kathryn E. Hentges, Amander T. Clark, Hisashi Nakamura, Andrew P. Salinger, Bin Liu, Neil Box, David W. Stockton, Randy L. Johnson, Richard R. Behringer, Allan Bradley and Monica J. Justice

doi:10.1038/nature01865

First paragraph | Full Text | PDF (403K) | Supplementary information

See also: News and Views by Rossant

The plastid clpP1 protease gene is essential for plant development p86

Hiroshi Kuroda and Pal Maliga

doi:10.1038/nature01909

First paragraph | Full Text | PDF (334K)

Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR- p90

Jin Fu, Silvana Gaetani, Fariba Oveisi, Jesse Lo Verme, Antonia Serrano, Fernando Rodríguez de Fonseca, Anja Rosengarth, Hartmut Luecke, Barbara Di Giacomo, Giorgio Tarzia and Daniele Piomelli

doi:10.1038/nature01921

First paragraph | Full Text | PDF (341K) | Supplementary information

Proton-sensing G-protein-coupled receptors p93

Marie-Gabrielle Ludwig, Miroslava Vanek, Danilo Guerini, Jürg A. Gasser, Carol E. Jones, Uwe Junker, Hans Hofstetter, Romain M. Wolf and Klaus Seuwen

doi:10.1038/nature01905

First paragraph | Full Text | PDF (653K) | Supplementary information

Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules p98

Byung-Je Sung, Kwang Yeon Hwang, Young Ho Jeon, Jae Il Lee, Yong-Seok Heo, Jin Hwan Kim, Jinho Moon, Jung Min Yoon, Young-Lan Hyun, Eunmi Kim, Sung Jin Eum, Sam-Yong Park, Jie-Oh Lee, Tae Gyu Lee, Seonggu Ro and Joong Myung Cho

doi:10.1038/nature01914

First paragraph | Full Text | PDF (436K) | Supplementary information

Corrigendum: Structure of the replicative helicase of the oncoprotein SV40 large tumour antigen p102

Dawei Li, Rui Zhao, Wayne Lilyestrom, Dahai Gai, Rongguang Zhang, James A. DeCaprio, Ellen Fanning, Andrzej Joachimiak, Gerda Szakonyi and Xiaojiang S. Chen

doi:10.1038/nature01896

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Erratum: The expression domain of PHANTASTICA determines leaflet placement in compound leaves p102

Minsung Kim, Sheila McCormick, Marja Timmermans and Neelima Sinha

doi:10.1038/nature01924

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Corrigendum: Impact of urbanization and land-use change on climate p102

E. Kalnay and M. Cai

doi:10.1038/nature01952

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Naturejobs

Rental disagreements p103

Paul Smaglik

doi:10.1038/nj6953-103a

Full Text | PDF (93K)

Investing to compete Ontario p104

David Spurgeon

doi:10.1038/nj6953-104a

Full Text | PDF (154K)