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Nature 425, 27-28 (4 September 2003) | doi:10.1038/425027a

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Cell biology: Join the crowd

R. John Ellis1 & Allen P. Minton2

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Cells are packed with large molecules. The ramifications of this 'crowding' for a wide range of intracellular processes are only now becoming more generally understood.

All cells contain lots of big molecules, especially proteins, nucleic acids and complex sugars. The very high total concentration of these molecules, or 'macromolecular crowding', has energetic consequences that could affect many aspects of cellular function.

  1. Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, UK.
    Email: jellis@bio.warwick.ac.uk
  2. National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland 20892-0830, USA.
    Email: minton@helix.nih.gov