FIGURE 4. OEA regulates gene expression through PPAR-
activation.
From the following article:
Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-
Jin Fu, Silvana Gaetani, Fariba Oveisi, Jesse Lo Verme, Antonia Serrano, Fernando Rodríguez de Fonseca, Anja Rosengarth, Hartmut Luecke, Barbara Di Giacomo, Giorgio Tarzia and Daniele Piomelli
Nature 425, 90-93(4 September 2003)
doi:10.1038/nature01921
a–d, Effects of vehicle (V), Wy-14643 (W; 30 mg per kg i.p.) and OEA (O; 10 mg per kg i.p.) on messenger RNA levels of PPAR- (a), FAT/CD36 (b), FATP1 (c) and PPAR-
/
, PPAR-
and I-FABP (d) in the jejunum of wild-type and PPAR--/- mice (n = 5). e–g, Effects of vehicle (V), Wy-14643 (W; 30 mg per kg i.p.) and OEA (O; 10 mg per kg i.p.) on mRNA levels of PPAR- (e), FAT/CD36 (f) and L-FABP (g) in the liver of wild-type and PPAR--/- mice (n = 5). h, Transrepression of iNOS expression by OEA (O; 10 mg per kg i.p.) and Wy-14643 (W; 30 mg per kg i.p.) in the jejunum of C57BL/6J mice (n = 5). mRNA levels are expressed in arbitrary units. *P < 0.05 and **P < 0.001 by one-way ANOVA followed by Dunnett's test.
