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Editorials

No way to run a superpower p861

The scientific community had low expectations for the Bush administration when it was first elected. The record since 2001 shows that these expectations were justified.

doi:10.1038/424861a


Goodbye, flat biology? p861

Seductive higher dimensions could consign glass dishes to history.

doi:10.1038/424861b


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News

NASA braced for culture shock as Columbia inquiry reaches verdict p863

Tony Reichhardt

doi:10.1038/424863a


Bioweapons initiatives bogged down in talks p865

Erika Check

doi:10.1038/424865a


Paired-up helium atoms make it big p865

Geoff Brumfiel

doi:10.1038/424865b


Accrued HIV evidence turns treatment dogma on its head p866

Erika Check

doi:10.1038/424866a


Water worlds make a splash as the best hope for alien life p866

Quirin Schiermeier

doi:10.1038/424866b


Heatwave underlines climate-model failures p867

Declan Butler

doi:10.1038/424867a


Europe insists fusion-project race remains wide open p867

Declan Butler

doi:10.1038/424867b


News in brief p868

doi:10.1038/424868a


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News Features

Cell culture: Biology's new dimension p870

There's a big difference between a flat layer of cells and a complex, three-dimensional tissue. But until recently, many biologists have glossed over this fact. Alison Abbott discovers what they've been missing.

doi:10.1038/424870a


Take a deep breath p873

Want to know what's going on inside your lungs? Conventional imaging techniques are not much use, but by inhaling a magnetized gas you could get a clear picture of your airways. Erica Klarreich investigates.

doi:10.1038/424873a


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Correspondence

Need for a court to rule on patents and misconduct p875

Scientific affairs are too complex to be solved locally, says a researcher cleared of fraud.

Bernard E. Bihain

doi:10.1038/424875a


Haeckel's literary hopes dashed by materialism? p875

Uwe Hossfeld, Rosemarie Nöthlich and Lennart Olsson

doi:10.1038/424875b


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Commentary

Who said 'helix'? p876

Right and wrong in the story of how the structure of DNA was discovered.

doi:10.1038/424876a


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Books and Arts

Finding the time p879

The scientific struggle to bring the world's clocks into line.

Jeremy Gray reviews Einstein's Clocks and Poincaré's Maps: Empires of Time by Peter Galison

doi:10.1038/424879a


Fountain of hype p880

S. Jay Olshansky reviews Merchants of Immortality: Chasing the Dream of Human Life Extension by Stephen Hall

doi:10.1038/424880a


Ecology you can count on p881

Alan Hastings reviews Population Ecology: First Principles by John H. Vandermeer and Deborah E. Goldberg

doi:10.1038/424881a


Petal power p881

doi:10.1038/424881b


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Concepts

Systems biology: Understanding cells p883

New approaches are needed to determine the logical and informational processes that underpin cellular behaviour.

Paul Nurse

doi:10.1038/424883a


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News and Views

Zoology: You aren't what you eat p885

An obscure marine worm does not belong among the molluscs, as had been thought. Rather, it has a claim to being the most primitive extant member of the group of animals that includes vertebrates.

Henry Gee

doi:10.1038/424885a


Granular materials: Shaken sand — a granular fluid? p886

The connection between random grain motion and viscosity in shaken sand — a strongly non-equilibrium system — has been probed. Curiously, the link is similar to that found in an ordinary liquid in thermal equilibrium.

Paul Umbanhowar

doi:10.1038/424886a


Malaria: To kill a parasite p887

Artemisinins have been used since ancient times to treat malaria. A new theory could explain how this age-old medicine is able to cause the death of the malaria parasite.

Robert G. Ridley

doi:10.1038/424887a


Cell biology: Tumour jailbreak p889

New work shows that a cage-like matrix of protein fibres around cells can inhibit the growth of tumours. But cancer cells producing the enzyme MT1-MMP can cleave this matrix and proliferate freely.

Kenneth M. Yamada

doi:10.1038/424889a


Archaeology: Propaganda of the pyramids p891

You would have thought that massive monuments would be built by states at the apogee of their pomp and glory. Not so, according to an argument in which it is states on the up that need to impress.

Jared Diamond

doi:10.1038/424891a


100 and 50 years ago p891

doi:10.1038/424891b


Earth science: Tiny triggers deep down p893

The documentation and characterization of remotely triggered earthquakes deep within the Earth is an achievement that provides insight into the mechanisms that initiate such events.

Harry W. Green, II

doi:10.1038/424893a


Developmental biology: Hotspots for evolution p894

Two studies of fruitflies suggest that although development relies on a diverse toolkit of genes, the evolution of physical characteristics might be powered by variation in just a few of these tools.

Michael K. Richardson and Paul M. Brakefield

doi:10.1038/424894a


Mathematics: The 24-dimensional greengrocer p895

The best way to stack oranges has been evident in markets around the world for centuries, but the mathematics of the problem is far from trivial. The solution for the 24-dimensional case is now within reach.

Ian Stewart

doi:10.1038/424895a


Cell biology: Metabolism meets death p896

A protein that controls cell death has been found in a complex with a protein involved in glucose metabolism. Is this a point of contact between these two crucial cellular processes?

Julian Downward

doi:10.1038/424896a


News and views in brief p898

doi:10.1038/424898a


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Brief Communications

Fibre-optical features of a glass sponge p899

Some superior technological secrets have come to light from a deep-sea organism.

Vikram C. Sundar, Andrew D. Yablon, John L. Grazul, Micha Ilan and Joanna Aizenberg

doi:10.1038/424899a


Linguistics: Modelling the dynamics of language death p900

Daniel M. Abrams and Steven H. Strogatz

doi:10.1038/424900a


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Review

The role of stomata in sensing and driving environmental change p901

Alistair M. Hetherington and F. Ian Woodward

doi:10.1038/nature01843


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Letters to Nature

Observing brownian motion in vibration-fluidized granular matter p909

G. D'Anna, P. Mayor, A. Barrat, V. Loreto and Franco Nori

doi:10.1038/nature01867

See also: News and Views by Umbanhowar


Signature of optimal doping in Hall-effect measurements on a high-temperature superconductor p912

Fedor F. Balakirev, Jonathan B. Betts, Albert Migliori, S. Ono, Yoichi Ando and Gregory S. Boebinger

doi:10.1038/nature01890


Epoxidation of polybutadiene by a topologically linked catalyst p915

Pall Thordarson, Edward J. A. Bijsterveld, Alan E. Rowan and Roeland J. M. Nolte

doi:10.1038/nature01925


Extreme deuterium enrichment in stratospheric hydrogen and the global atmospheric budget of H2 p918

Thom Rahn, John M. Eiler, Kristie A. Boering, Paul O. Wennberg, Michael C. McCarthy, Stanley Tyler, Sue Schauffler, Stephen Donnelly and Elliot Atlas

doi:10.1038/nature01917


Remote triggering of deep earthquakes in the 2002 Tonga sequences p921

Rigobert Tibi, Douglas A. Wiens and Hiroshi Inoue

doi:10.1038/nature01903

See also: News and Views by Green


Xenoturbella is a deuterostome that eats molluscs p925

Sarah J. Bourlat, Claus Nielsen, Anne E. Lockyer, D. Timothy J. Littlewood and Maximilian J. Telford

doi:10.1038/nature01851

See also: News and Views by Gee


Speciation by host switch in brood parasitic indigobirds p928

Michael D. Sorenson, Kristina M. Sefc and Robert B. Payne

doi:10.1038/nature01863


Genetic mechanisms and constraints governing the evolution of correlated traits in drosophilid flies p931

Nicolas Gompel and Sean B. Carroll

doi:10.1038/nature01787


Regulatory evolution of shavenbaby/ovo underlies multiple cases of morphological parallelism p935

Elio Sucena, Isabelle Delon, Isaac Jones, François Payre and David L. Stern

doi:10.1038/nature01768


Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain p938

Jeffrey A. M. Coull, Dominic Boudreau, Karine Bachand, Steven A. Prescott, Francine Nault, Attila Sík, Paul De Koninck and Yves De Koninck

doi:10.1038/nature01868


Different domains of synaptotagmin control the choice between kiss-and-run and full fusion p943

Chih-Tien Wang, Juu-Chin Lu, Jihong Bai, Payne Y. Chang, Thomas F. J. Martin, Edwin R. Chapman and Meyer B. Jackson

doi:10.1038/nature01857


Generation of prion transmission barriers by mutational control of amyloid conformations p948

Peter Chien, Angela H. DePace, Sean R. Collins and Jonathan S. Weissman

doi:10.1038/nature01894


BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis p952

Nika N. Danial, Colette F. Gramm, Luca Scorrano, Chen-Yu Zhang, Stefan Krauss, Ann M. Ranger, Sandeep Robert Datta, Michael E. Greenberg, Lawrence J. Licklider, Bradford B. Lowell, Steven P. Gygi and Stanley J. Korsmeyer

doi:10.1038/nature01825

See also: News and Views by Downward


Artemisinins target the SERCA of Plasmodium falciparum p957

U. Eckstein-Ludwig, R. J. Webb, I. D. A. van Goethem, J. M. East, A. G. Lee, M. Kimura, P. M. O'Neill, P. G. Bray, S. A. Ward and S. Krishna

doi:10.1038/nature01813

See also: News and Views by Ridley


Feedback regulation of MAPK signalling by an RNA-binding protein p961

Reiko Sugiura, Ayako Kita, Yasuhito Shimizu, Hisato Shuntoh, Susie O. Sio and Takayoshi Kuno

doi:10.1038/nature01907


Transcription factor IIB acetylates itself to regulate transcription p965

Chu H. Choi, Makoto Hiromura and Anny Usheva

doi:10.1038/nature01899


Complex between nidogen and laminin fragments reveals a paradigmatic beta-propeller interface p969

Junichi Takagi, Yuting Yang, Jin-huan Liu, Jia-huai Wang and Timothy A. Springer

doi:10.1038/nature01873


Erratum: Links between signal transduction, transcription and adhesion in epithelial bud development p974

Colin Jamora, Ramanuj DasGupta, Pawel Kocieniewski and Elaine Fuchs

doi:10.1038/nature01893


Corrigendum: 146Sm-142Nd evidence from Isua metamorphosed sediments for early differentiation of the Earth's mantle p974

Guillaume Caro, Bernard Bourdon, Jean-Louis Birck and Stephen Moorbath

doi:10.1038/nature01897


Erratum: Class 3 semaphorins control vascular morphogenesis by inhibiting integrin function p974

Guldo Serini, Donatella Valdembri, Sara Zanivan, Giulia Morterra, Constanze Burkhardt, Francesca Caccavarl, Luca Zammataro, Luca Primo, Luca Tamagnone, Malcolm Logan, Marc Tessier-Lavigne, Masahiko Taniguchl, Andreas W. Püschel and Federico Bussolino

doi:10.1038/nature01946


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New on the Market

Antibodies in abundance p975

The latest offerings for immunology.

doi:10.1038/424975a


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Naturejobs

Prospects

Fears for foreign physicists p979

Paul Smaglik

doi:10.1038/nj6951-979a


MOVERS

Movers p980

doi:10.1038/nj6951-980a


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