Table of contents
Volume 424 Number 6951 pp861-980
Editorials
No way to run a superpower p861
The scientific community had low expectations for the Bush administration when it was first elected. The record since 2001 shows that these expectations were justified.
doi:10.1038/424861a
Goodbye, flat biology? p861
Seductive higher dimensions could consign glass dishes to history.
doi:10.1038/424861b
News
NASA braced for culture shock as Columbia inquiry reaches verdict p863
Tony Reichhardt
doi:10.1038/424863a
Bioweapons initiatives bogged down in talks p865
Erika Check
doi:10.1038/424865a
Paired-up helium atoms make it big p865
Geoff Brumfiel
doi:10.1038/424865b
Accrued HIV evidence turns treatment dogma on its head p866
Erika Check
doi:10.1038/424866a
Water worlds make a splash as the best hope for alien life p866
Quirin Schiermeier
doi:10.1038/424866b
Heatwave underlines climate-model failures p867
Declan Butler
doi:10.1038/424867a
Europe insists fusion-project race remains wide open p867
Declan Butler
doi:10.1038/424867b
News Features
Cell culture: Biology's new dimension p870
There's a big difference between a flat layer of cells and a complex, three-dimensional tissue. But until recently, many biologists have glossed over this fact. Alison Abbott discovers what they've been missing.
doi:10.1038/424870a
Take a deep breath p873
Want to know what's going on inside your lungs? Conventional imaging techniques are not much use, but by inhaling a magnetized gas you could get a clear picture of your airways. Erica Klarreich investigates.
doi:10.1038/424873a
Correspondence
Need for a court to rule on patents and misconduct p875
Scientific affairs are too complex to be solved locally, says a researcher cleared of fraud.
Bernard E. Bihain
doi:10.1038/424875a
Haeckel's literary hopes dashed by materialism? p875
Uwe Hossfeld, Rosemarie Nöthlich and Lennart Olsson
doi:10.1038/424875b
Commentary
Who said 'helix'? p876
Right and wrong in the story of how the structure of DNA was discovered.
doi:10.1038/424876a
Books and Arts
Finding the time p879
The scientific struggle to bring the world's clocks into line.
Jeremy Gray reviews Einstein's Clocks and Poincaré's Maps: Empires of Time by Peter Galison
doi:10.1038/424879a
Fountain of hype p880
S. Jay Olshansky reviews Merchants of Immortality: Chasing the Dream of Human Life Extension by Stephen Hall
doi:10.1038/424880a
Ecology you can count on p881
Alan Hastings reviews Population Ecology: First Principles by John H. Vandermeer and Deborah E. Goldberg
doi:10.1038/424881a
Petal power p881
doi:10.1038/424881b
Concepts
Systems biology: Understanding cells p883
New approaches are needed to determine the logical and informational processes that underpin cellular behaviour.
Paul Nurse
doi:10.1038/424883a
News and Views
Zoology: You aren't what you eat p885
An obscure marine worm does not belong among the molluscs, as had been thought. Rather, it has a claim to being the most primitive extant member of the group of animals that includes vertebrates.
Henry Gee
doi:10.1038/424885a
Granular materials: Shaken sand — a granular fluid? p886
The connection between random grain motion and viscosity in shaken sand — a strongly non-equilibrium system — has been probed. Curiously, the link is similar to that found in an ordinary liquid in thermal equilibrium.
Paul Umbanhowar
doi:10.1038/424886a
Malaria: To kill a parasite p887
Artemisinins have been used since ancient times to treat malaria. A new theory could explain how this age-old medicine is able to cause the death of the malaria parasite.
Robert G. Ridley
doi:10.1038/424887a
Cell biology: Tumour jailbreak p889
New work shows that a cage-like matrix of protein fibres around cells can inhibit the growth of tumours. But cancer cells producing the enzyme MT1-MMP can cleave this matrix and proliferate freely.
Kenneth M. Yamada
doi:10.1038/424889a
Archaeology: Propaganda of the pyramids p891
You would have thought that massive monuments would be built by states at the apogee of their pomp and glory. Not so, according to an argument in which it is states on the up that need to impress.
Jared Diamond
doi:10.1038/424891a
100 and 50 years ago p891
doi:10.1038/424891b
Earth science: Tiny triggers deep down p893
The documentation and characterization of remotely triggered earthquakes deep within the Earth is an achievement that provides insight into the mechanisms that initiate such events.
Harry W. Green, II
doi:10.1038/424893a
Developmental biology: Hotspots for evolution p894
Two studies of fruitflies suggest that although development relies on a diverse toolkit of genes, the evolution of physical characteristics might be powered by variation in just a few of these tools.
Michael K. Richardson and Paul M. Brakefield
doi:10.1038/424894a
Mathematics: The 24-dimensional greengrocer p895
The best way to stack oranges has been evident in markets around the world for centuries, but the mathematics of the problem is far from trivial. The solution for the 24-dimensional case is now within reach.
Ian Stewart
doi:10.1038/424895a
Cell biology: Metabolism meets death p896
A protein that controls cell death has been found in a complex with a protein involved in glucose metabolism. Is this a point of contact between these two crucial cellular processes?
Julian Downward
doi:10.1038/424896a
News and views in brief p898
doi:10.1038/424898a
Brief Communications
Fibre-optical features of a glass sponge p899
Some superior technological secrets have come to light from a deep-sea organism.
Vikram C. Sundar, Andrew D. Yablon, John L. Grazul, Micha Ilan and Joanna Aizenberg
doi:10.1038/424899a
First paragraph | Full Text | PDF (114K)
Linguistics: Modelling the dynamics of language death p900
Daniel M. Abrams and Steven H. Strogatz
doi:10.1038/424900a
First paragraph | Full Text | PDF (67K)
Review
The role of stomata in sensing and driving environmental change p901
Alistair M. Hetherington and F. Ian Woodward
doi:10.1038/nature01843
Abstract | Full Text | PDF (370K)
Letters to Nature
Observing brownian motion in vibration-fluidized granular matter p909
G. D'Anna, P. Mayor, A. Barrat, V. Loreto and Franco Nori
doi:10.1038/nature01867
First paragraph | Full Text | PDF (412K)
See also: News and Views by Umbanhowar
Signature of optimal doping in Hall-effect measurements on a high-temperature superconductor p912
Fedor F. Balakirev, Jonathan B. Betts, Albert Migliori, S. Ono, Yoichi Ando and Gregory S. Boebinger
doi:10.1038/nature01890
First paragraph | Full Text | PDF (267K)
Epoxidation of polybutadiene by a topologically linked catalyst p915
Pall Thordarson, Edward J. A. Bijsterveld, Alan E. Rowan and Roeland J. M. Nolte
doi:10.1038/nature01925
First paragraph | Full Text | PDF (288K) | Supplementary information
Extreme deuterium enrichment in stratospheric hydrogen and the global atmospheric budget of H2 p918
Thom Rahn, John M. Eiler, Kristie A. Boering, Paul O. Wennberg, Michael C. McCarthy, Stanley Tyler, Sue Schauffler, Stephen Donnelly and Elliot Atlas
doi:10.1038/nature01917
First paragraph | Full Text | PDF (247K) | Supplementary information
Remote triggering of deep earthquakes in the 2002 Tonga sequences p921
Rigobert Tibi, Douglas A. Wiens and Hiroshi Inoue
doi:10.1038/nature01903
First paragraph | Full Text | PDF (444K) | Supplementary information
See also: News and Views by Green
Xenoturbella is a deuterostome that eats molluscs p925
Sarah J. Bourlat, Claus Nielsen, Anne E. Lockyer, D. Timothy J. Littlewood and Maximilian J. Telford
doi:10.1038/nature01851
First paragraph | Full Text | PDF (381K) | Supplementary information
See also: News and Views by Gee
Speciation by host switch in brood parasitic indigobirds p928
Michael D. Sorenson, Kristina M. Sefc and Robert B. Payne
doi:10.1038/nature01863
First paragraph | Full Text | PDF (502K) | Supplementary information
Genetic mechanisms and constraints governing the evolution of correlated traits in drosophilid flies p931
Nicolas Gompel and Sean B. Carroll
doi:10.1038/nature01787
First paragraph | Full Text | PDF (506K)
Regulatory evolution of shavenbaby/ovo underlies multiple cases of morphological parallelism p935
Elio Sucena, Isabelle Delon, Isaac Jones, François Payre and David L. Stern
doi:10.1038/nature01768
First paragraph | Full Text | PDF (666K) | Supplementary information
Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain p938
Jeffrey A. M. Coull, Dominic Boudreau, Karine Bachand, Steven A. Prescott, Francine Nault, Attila Sík, Paul De Koninck and Yves De Koninck
doi:10.1038/nature01868
First paragraph | Full Text | PDF (463K) | Supplementary information
Different domains of synaptotagmin control the choice between kiss-and-run and full fusion p943
Chih-Tien Wang, Juu-Chin Lu, Jihong Bai, Payne Y. Chang, Thomas F. J. Martin, Edwin R. Chapman and Meyer B. Jackson
doi:10.1038/nature01857
First paragraph | Full Text | PDF (454K) | Supplementary information
Generation of prion transmission barriers by mutational control of amyloid conformations p948
Peter Chien, Angela H. DePace, Sean R. Collins and Jonathan S. Weissman
doi:10.1038/nature01894
First paragraph | Full Text | PDF (387K) | Supplementary information
BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis p952
Nika N. Danial, Colette F. Gramm, Luca Scorrano, Chen-Yu Zhang, Stefan Krauss, Ann M. Ranger, Sandeep Robert Datta, Michael E. Greenberg, Lawrence J. Licklider, Bradford B. Lowell, Steven P. Gygi and Stanley J. Korsmeyer
doi:10.1038/nature01825
First paragraph | Full Text | PDF (477K) | Supplementary information
See also: News and Views by Downward
Artemisinins target the SERCA of Plasmodium falciparum p957
U. Eckstein-Ludwig, R. J. Webb, I. D. A. van Goethem, J. M. East, A. G. Lee, M. Kimura, P. M. O'Neill, P. G. Bray, S. A. Ward and S. Krishna
doi:10.1038/nature01813
First paragraph | Full Text | PDF (364K)
See also: News and Views by Ridley
Feedback regulation of MAPK signalling by an RNA-binding protein p961
Reiko Sugiura, Ayako Kita, Yasuhito Shimizu, Hisato Shuntoh, Susie O. Sio and Takayoshi Kuno
doi:10.1038/nature01907
First paragraph | Full Text | PDF (451K) | Supplementary information
Transcription factor IIB acetylates itself to regulate transcription p965
Chu H. Choi, Makoto Hiromura and Anny Usheva
doi:10.1038/nature01899
First paragraph | Full Text | PDF (386K) | Supplementary information
Complex between nidogen and laminin fragments reveals a paradigmatic 
-propeller interface p969
Junichi Takagi, Yuting Yang, Jin-huan Liu, Jia-huai Wang and Timothy A. Springer
doi:10.1038/nature01873
First paragraph | Full Text | PDF (659K) | Supplementary information
Erratum: Links between signal transduction, transcription and adhesion in epithelial bud development p974
Colin Jamora, Ramanuj DasGupta, Pawel Kocieniewski and Elaine Fuchs
doi:10.1038/nature01893
Corrigendum: 146Sm-142Nd evidence from Isua metamorphosed sediments for early differentiation of the Earth's mantle p974
Guillaume Caro, Bernard Bourdon, Jean-Louis Birck and Stephen Moorbath
doi:10.1038/nature01897
Erratum: Class 3 semaphorins control vascular morphogenesis by inhibiting integrin function p974
Guldo Serini, Donatella Valdembri, Sara Zanivan, Giulia Morterra, Constanze Burkhardt, Francesca Caccavarl, Luca Zammataro, Luca Primo, Luca Tamagnone, Malcolm Logan, Marc Tessier-Lavigne, Masahiko Taniguchl, Andreas W. Püschel and Federico Bussolino
doi:10.1038/nature01946
New on the Market
Antibodies in abundance p975
The latest offerings for immunology.
doi:10.1038/424975a
Naturejobs
ProspectsFears for foreign physicists p979
Paul Smaglik
doi:10.1038/nj6951-979a
MOVERS
Movers p980
doi:10.1038/nj6951-980a
