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Nature 424, 732-734 (14 August 2003) | doi:10.1038/424732a
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Cancer: Protective packaging for DNA
Jessica A. Downs1 & Stephen P. Jackson2
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Abstract
Histone proteins are best known for their structural role in packaging DNA into a compact form. But it seems that one such protein also works as a tumour suppressor, helping to prevent cancer developing.
Inside every human cell there is an impressive two metres or so of DNA, which must be organized into a compact form to fit into the cell nucleus. To do this, cells begin by wrapping the DNA around histone proteins.
- Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, UK.
Email: js4@mole.bio.cam.ac.uk - Wellcome Trust/Cancer Research UK Institute, Tennis Court Road, Cambridge CB2 1QR, UK.
Email: spj13@mole.bio.cam.ac.uk
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