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Nature 424, 729-730 (14 August 2003) | doi:10.1038/424729a
Neurobiology: New player in pain
Edwin W. McCleskey1
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Abstract
Long-term pain must be accompanied by long-term alterations in neuronal signalling — but what causes the changes? In rats, immune-like spinal cells are implicated, together with a molecule new to the field of pain.
Normally essential to warn us of danger, pain becomes harmful when it occurs without any evident stimulus. If this persists, it can cripple a person's life.
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