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Nature 424, 729-730 (14 August 2003) | doi:10.1038/424729a

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Neurobiology: New player in pain

Edwin W. McCleskey1

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Long-term pain must be accompanied by long-term alterations in neuronal signalling — but what causes the changes? In rats, immune-like spinal cells are implicated, together with a molecule new to the field of pain.

Normally essential to warn us of danger, pain becomes harmful when it occurs without any evident stimulus. If this persists, it can cripple a person's life.

  1. Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239, USA.
    Email: mccleske@ohsu.edu