Supplementary information
From the following article:
The DNA sequence of human chromosome 7
LaDeana W. Hillier, Robert S. Fulton, Lucinda A. Fulton, Tina A. Graves, Kymberlie H. Pepin, Caryn Wagner-McPherson, Dan Layman, Jason Maas, Sara Jaeger, Rebecca Walker, Kristine Wylie, Mandeep Sekhon, Michael C. Becker, Michelle D. O'Laughlin, Mark E. Schaller, Ginger A. Fewell, Kimberly D. Delehaunty, Tracie L. Miner, William E. Nash, Matt Cordes, Hui Du, Hui Sun, Jennifer Edwards, Holland Bradshaw-Cordum, Johar Ali, Stephanie Andrews, Amber Isak, Andrew VanBrunt, Christine Nguyen, Feiyu Du, Betty Lamar, Laura Courtney, Joelle Kalicki, Philip Ozersky, Lauren Bielicki, Kelsi Scott, Andrea Holmes, Richard Harkins, Anthony Harris, Cynthia Madsen Strong, Shunfang Hou, Chad Tomlinson, Sara Dauphin-Kohlberg, Amy Kozlowicz-Reilly, Shawn Leonard, Theresa Rohlfing, Susan M. Rock, Aye-Mon Tin-Wollam, Amanda Abbott, Patrick Minx, Rachel Maupin, Catrina Strowmatt, Phil Latreille, Nancy Miller, Doug Johnson, Jennifer Murray, Jeffrey P. Woessner, Michael C. Wendl, Shiaw-Pyng Yang, Brian R. Schultz, John W. Wallis, John Spieth, Tamberlyn A. Bieri, Joanne O. Nelson, Nicolas Berkowicz, Patricia E. Wohldmann, Lisa L. Cook, Matthew T. Hickenbotham, James Eldred, Donald Williams, Joseph A. Bedell, Elaine R. Mardis, Sandra W. Clifton, Stephanie L. Chissoe, Marco A. Marra, Christopher Raymond, Eric Haugen, Will Gillett, Yang Zhou, Rose James, Karen Phelps, Shawn Iadanoto, Kerry Bubb, Elizabeth Simms, Ruth Levy, James Clendenning, Rajinder Kaul, W. James Kent, Terrence S. Furey, Robert A. Baertsch, Michael R. Brent, Evan Keibler, Paul Flicek, Peer Bork, Mikita Suyama, Jeffrey A. Bailey, Matthew E. Portnoy, David Torrents, Asif T. Chinwalla, Warren R. Gish, Sean R. Eddy, John D. McPherson, Maynard V. Olson, Evan E. Eichler, Eric D. Green, Robert H. Waterston and Richard K. Wilson
Nature 424, 157-164(10 July 2003)
doi:10.1038/nature01782
Supplementary Table 1: Interspersed Repeat Content
Supplementary Table 2: Correlation of Common Repeats with GC and exonic content.
Supplementary Figure 1: Distribution of Segmental Duplications. A schematic of chromosome 7 segmental duplications depicting the location of interchromosomal (red) and intrachromosomal (blue) duplicated sequence. Each horizontal line represents 1 Mb of sequence, with tick marks every 200 kb. Sequencing gaps are represented as discontinuities within the horizontal line. Duplications detected by whole genome shotgun sequence are represented as green bars above the chromosome sequence. The centromere is purple. Alpha satellite (black) and beta satellite (grey) are bars below the sequence.
Supplementary Figure 2: Sequence Identity of Segmental Duplications. A schematic of chromosome 7 segmental duplications depicting the sequence identity of interchromosomal (red) and intrachromosomal (blue) duplicated sequence. Each horizontal line represents 1 Mb of sequence, with tick marks every 200 kb. The vertical axis shows the percent sequence identity. Different colored bars indicate chromosome assignment. Sequencing gaps are represented as discontinuities within the horizontal line.
Supplementary Figure 3: Segmental Duplication Length Distribution (
90% and 1kb). The total number of aligned bases was calculated for two categories of duplication (90-95% and 95-100% sequence identity). The length of each interchromosomal (red) and intrachromosomal (blue) alignment is shown. The relative proportion of large to small duplications decreases with decreasing sequence identity.
Supplementary Figure 4: Duplications flanking Williams-Beuren Syndrome region. The complex structure and interrelationship of sequence alignments is shown. Joining lines demarcate the begin and end points of the most highly similar (97% and 10 kb) alignments (most likely to mediate rearrangements) in the Williams Syndrome region. The alignments demonstrate extensive large-scale sequence variation including insertions, deletions and inversions among paralogous loci.
Supplementary Table 3: Putative rearrangement prone regions.
Supplementary Table 4: Known genes with duplicated exon sequence.
Supplementary Materials and Methods
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