Editorial

We have been warned p113

The world is celebrating the news that the SARS outbreak now seems to be contained. But the epidemic has revealed gaps in our defences against emerging viral diseases and the ever-looming threat of a flu pandemic.

doi:10.1038/424113a

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News

Science shunted to the sidelines as EU sets out its space agenda p115

Declan Butler

doi:10.1038/424115a

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Pest resistance feared as farmers flout rules p116

Tom Clarke

doi:10.1038/424116a

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Europe finds transgenic food hard to swallow p116

Jim Giles

doi:10.1038/424116b

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Survey reveals mixed feelings over scientific misconduct p117

Alison Abbott and Phillip Graf

doi:10.1038/424117a

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Europe split over move to loosen stem-cell regulations p117

Alison Abbott

doi:10.1038/424117b

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Drive for patent-free innovation gathers pace p118

Declan Butler

doi:10.1038/424118a

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Malaysia puts biovalley under wraps p118

David Cyranoski

doi:10.1038/424118b

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DNA-chip firm backs down over upgrade p119

John Whitfield

doi:10.1038/424119a

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UK shock tactics repel animal-rights activists in Japan p119

David Cyranoski

doi:10.1038/424119b

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News in brief p120

doi:10.1038/424120a

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News

Correction: Broad Institute p120

doi:10.1038/424120b

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News Feature

SARS: What have we learned? p121

It's less than four months since the World Health Organization issued global warnings about a mysterious and deadly form of pneumonia. Nature's reporters pose key questions about the outbreak, and assess our preparedness to deal with future viral threats.

doi:10.1038/424121a

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Correspondence

History and science united to vindicate Perutz p127

A generous team player, he was backed by colleagues in clearing his name over DNA.

Marta Paterlini

doi:10.1038/424127a

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Were Cro-Magnons too like us for DNA to tell? p127

Guido Barbujani and Giorgio Bertorelle

doi:10.1038/424127b

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Multitude of reference styles delays publication p127

David M. Leslie, Jr and Meredith J. Hamilton

doi:10.1038/424127c

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Writing: visuals are another story p128

Marek H. Dominiczak and Kathy McFall

doi:10.1038/424128a

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Writing: LEX and flexibility p128

Ava Brent

doi:10.1038/424128b

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Writing: the clear choice p128

Sheila McCormick

doi:10.1038/424128c

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Commentary

Hydrogen lifts off — with a heavy load p129

The dream of clean, usable energy needs to reflect practical reality.

doi:10.1038/424129a

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Books and Arts

A dish to die for p131

Apes are still killed for their meat, but awareness of their plight is growing.

Guy Cowlishaw reviews Eating Apes by Dale Petersen

doi:10.1038/424131a

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Design of paradise p132

Lawren Sack and Dina Dechmann review A Magic Web by Egbert Giles Leigh, Jr and Christian Ziegler

doi:10.1038/424132a

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Sex on the brain p132

Joyce F. Benenson reviews Essential Difference: Men, Women and the Extreme Male Brain/ Essential Difference: The Truth About the Male and Female Brain by Simon Baron-Cohen

doi:10.1038/424132b

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Science in culture p133

Colin Martin reviews

doi:10.1038/424133a

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Concepts

Bacterial communication: Tiny teamwork p134

E. Peter Greenberg

doi:10.1038/424134a

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News and Views

Chemistry: Catalyst hunt accelerates p135

High-throughput methods of synthesis and analysis are streamlining the search for new catalysts, reducing the timescale from years to days. A new class of polymerization catalysts is the latest discovery.

Virgil Percec

doi:10.1038/424135a

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HIV: Cross-talk and viral reservoirs p136

Even after intensive antiviral treatment, HIV-1 can lurk in reservoirs in the human body and then reappear. The complex pathways by which the virus creates such reservoirs are only now becoming clear.

Roger J. Pomerantz

doi:10.1038/424136a

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Planetary science: Pluto's atmospheric surprise p137

Last year, for the first time in 14 years, an alignment of stars with Pluto created an opportunity to observe the atmosphere of this most remote of planets. Though tenuous, the atmosphere has, remarkably, expanded.

William Hubbard

doi:10.1038/424137a

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Cell biology: The molecules that make muscle p138

The role of integrin proteins in the formation of skeletal muscle has been hotly debated, as studies of whole animals and of cultured cells have yielded conflicting results. The controversy may now be resolved.

Donald Gullberg

doi:10.1038/424138a

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100 and 50 years ago p139

doi:10.1038/424139a

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Tumour suppressors: Timing will tell p140

A sophisticated model of the effects of mutating the retinoblastoma gene reveals a window of opportunity in which cells can be released from the normal control of proliferation, before back-up mechanisms take effect.

Anton Berns

doi:10.1038/424140a

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Oceanography: Stirring times in the Atlantic p141

Set against certain other oceanographic phenomena in the northwest Atlantic, a class of brief and localized events that occur in the Irminger Sea may seem inconsequential. Not so, however.

Bob Dickson

doi:10.1038/424141a

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News and views in brief p143

doi:10.1038/424143a

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Brief Communications

Social hierarchies: Size and growth modification in clownfish p145

Sex change is not the only way these fish achieve dominance — they grow into the role.

Peter Buston

doi:10.1038/424145a

First paragraph | Full Text | PDF (132K)

Hydrogen bonding: Single enantiomers from a chiral-alcohol catalyst p146

Yong Huang, Aditya K. Unni, Avinash N. Thadani and Viresh H. Rawal

doi:10.1038/424146a

First paragraph | Full Text | PDF (70K) | Supplementary information

Review

Transcription regulation and animal diversity p147

Michael Levine and Robert Tjian

doi:10.1038/nature01763

Abstract | Full Text | PDF (332K)

Articles

Deep convection in the Irminger Sea forced by the Greenland tip jet p152

Robert S. Pickart, Michael A. Spall, Mads Hvid Ribergaard, G. W. K. Moore and Ralph F. Milliff

doi:10.1038/nature01729

Abstract | Full Text | PDF (552K)

See also: News and Views by Dickson

The DNA sequence of human chromosome 7 p157

LaDeana W. Hillier, Robert S. Fulton, Lucinda A. Fulton, Tina A. Graves, Kymberlie H. Pepin, Caryn Wagner-McPherson, Dan Layman, Jason Maas, Sara Jaeger, Rebecca Walker, Kristine Wylie, Mandeep Sekhon, Michael C. Becker, Michelle D. O'Laughlin, Mark E. Schaller, Ginger A. Fewell, Kimberly D. Delehaunty, Tracie L. Miner, William E. Nash, Matt Cordes, Hui Du, Hui Sun, Jennifer Edwards, Holland Bradshaw-Cordum, Johar Ali, Stephanie Andrews, Amber Isak, Andrew VanBrunt, Christine Nguyen, Feiyu Du, Betty Lamar, Laura Courtney, Joelle Kalicki, Philip Ozersky, Lauren Bielicki, Kelsi Scott, Andrea Holmes, Richard Harkins, Anthony Harris, Cynthia Madsen Strong, Shunfang Hou, Chad Tomlinson, Sara Dauphin-Kohlberg, Amy Kozlowicz-Reilly, Shawn Leonard, Theresa Rohlfing, Susan M. Rock, Aye-Mon Tin-Wollam, Amanda Abbott, Patrick Minx, Rachel Maupin, Catrina Strowmatt, Phil Latreille, Nancy Miller, Doug Johnson, Jennifer Murray, Jeffrey P. Woessner, Michael C. Wendl, Shiaw-Pyng Yang, Brian R. Schultz, John W. Wallis, John Spieth, Tamberlyn A. Bieri, Joanne O. Nelson, Nicolas Berkowicz, Patricia E. Wohldmann, Lisa L. Cook, Matthew T. Hickenbotham, James Eldred, Donald Williams, Joseph A. Bedell, Elaine R. Mardis, Sandra W. Clifton, Stephanie L. Chissoe, Marco A. Marra, Christopher Raymond, Eric Haugen, Will Gillett, Yang Zhou, Rose James, Karen Phelps, Shawn Iadanoto, Kerry Bubb, Elizabeth Simms, Ruth Levy, James Clendenning, Rajinder Kaul, W. James Kent, Terrence S. Furey, Robert A. Baertsch, Michael R. Brent, Evan Keibler, Paul Flicek, Peer Bork, Mikita Suyama, Jeffrey A. Bailey, Matthew E. Portnoy, David Torrents, Asif T. Chinwalla, Warren R. Gish, Sean R. Eddy, John D. McPherson, Maynard V. Olson, Evan E. Eichler, Eric D. Green, Robert H. Waterston and Richard K. Wilson

doi:10.1038/nature01782

Abstract | Full Text | PDF (502K) | Supplementary information

Letters to Nature

The recent expansion of Pluto's atmosphere p165

J. L. Elliot, A. Ates, B. A. Babcock, A. S. Bosh, M. W. Buie, K. B. Clancy, E. W. Dunham, S. S. Eikenberry, D. T. Hall, S. D. Kern, S. K. Leggett, S. E. Levine, D.-S. Moon, C. B. Olkin, D. J. Osip, J. M. Pasachoff, B. E. Penprase, M. J. Person, S. Qu, J. T. Rayner, L. C. Roberts, Jr, C. V. Salyk, S. P. Souza, R. C. Stone, B. W. Taylor, D. J. Tholen, J. E. Thomas-Osip, D. R. Ticehurst and L. H. Wasserman

doi:10.1038/nature01762

First paragraph | Full Text | PDF (274K) | Supplementary information

See also: News and Views by Hubbard

Large changes in Pluto's atmosphere as revealed by recent stellar occultations p168

B. Sicardy, T. Widemann, E. Lellouch, C. Veillet, J.-C. Cuillandre, F. Colas, F. Roques, W. Beisker, M. Kretlow, A.-M. Lagrange, E. Gendron, F. Lacombe, J. Lecacheux, C. Birnbaum, A. Fienga, C. Leyrat, A. Maury, E. Raynaud, S. Renner, M. Schultheis, K. Brooks, A. Delsanti, O. R. Hainaut, R. Gilmozzi, C. Lidman, J. Spyromilio, M. Rapaport, P. Rosenzweig, O. Naranjo, L. Porras, F. Díaz, H. Calderón, S. Carrillo, A. Carvajal, E. Recalde, L. Gaviria Cavero, C. Montalvo, D. Barría, R. Campos, R. Duffard and H. Levato

doi:10.1038/nature01766

First paragraph | Full Text | PDF (203K)

See also: News and Views by Hubbard

Miniaturized gas ionization sensors using carbon nanotubes p171

Ashish Modi, Nikhil Koratkar, Eric Lass, Bingqing Wei and Pulickel M. Ajayan

doi:10.1038/nature01777

First paragraph | Full Text | PDF (281K) | Supplementary information

Unidirectional rotation in a mechanically interlocked molecular rotor p174

David A. Leigh, Jenny K. Y. Wong, François Dehez and Francesco Zerbetto

doi:10.1038/nature01758

First paragraph | Full Text | PDF (728K) | Supplementary information

Post-earthquake ground movements correlated to pore-pressure transients p179

Sigurjón Jónsson, Paul Segall, Rikke Pedersen and Grímur Björnsson

doi:10.1038/nature01776

First paragraph | Full Text | PDF (1,314K)

Urbanization effects on tree growth in the vicinity of New York City p183

Jillian W. Gregg, Clive G. Jones and Todd E. Dawson

doi:10.1038/nature01728

First paragraph | Full Text | PDF (309K)

Strong population substructure is correlated with morphology and ecology in a migratory bat p187

Cassandra M. Miller-Butterworth, David S. Jacobs and Eric H. Harley

doi:10.1038/nature01742

First paragraph | Full Text | PDF (296K) | Supplementary information

Captivity masks inbreeding effects on male mating success in butterflies p191

Mathieu Joron and Paul M. Brakefield

doi:10.1038/nature01713

First paragraph | Full Text | PDF (191K) | Supplementary information

Dosage sensitivity and the evolution of gene families in yeast p194

Balázs Papp, Csaba Pál and Laurence D. Hurst

doi:10.1038/nature01771

First paragraph | Full Text | PDF (166K) | Supplementary information

Widespread horizontal transfer of mitochondrial genes in flowering plants p197

Ulfar Bergthorsson, Keith L. Adams, Brendan Thomason and Jeffrey D. Palmer

doi:10.1038/nature01743

First paragraph | Full Text | PDF (703K) | Supplementary information

Topography and synaptic shaping of direction selectivity in primary auditory cortex p201

Li I. Zhang, Andrew Y. Y. Tan, Christoph E. Schreiner and Michael M. Merzenich

doi:10.1038/nature01796

First paragraph | Full Text | PDF (2,464K) | Supplementary information

Glutamate-receptor-mediated encoding and retrieval of paired-associate learning p205

M. Day, R. Langston and R. G. M. Morris

doi:10.1038/nature01769

First paragraph | Full Text | PDF (283K) | Supplementary information

T-type calcium channel regulation by specific G-protein subunits p209

Joshua T. Wolfe, Hongge Wang, Jason Howard, James C. Garrison and Paula Q. Barrett

doi:10.1038/nature01772

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HIV-1 Nef intersects the macrophage CD40L signalling pathway to promote resting-cell infection p213

Simon Swingler, Beda Brichacek, Jean-Marc Jacque, Catherine Ulich, Jin Zhou and Mario Stevenson

doi:10.1038/nature01749

First paragraph | Full Text | PDF (459K)

See also: News and Views by Pomerantz

JNK phosphorylates paxillin and regulates cell migration p219

Cai Huang, Zenon Rajfur, Christoph Borchers, Michael D. Schaller and Ken Jacobson

doi:10.1038/nature01745

First paragraph | Full Text | PDF (607K) | Supplementary information

Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry p223

Julien Sage, Abigail L. Miller, Pedro A. Pérez-Mancera, Julianne M. Wysocki and Tyler Jacks

doi:10.1038/nature01764

First paragraph | Full Text | PDF (320K) | Supplementary information

See also: News and Views by Berns

Xpd/Ercc2 regulates CAK activity and mitotic progression p228

Jian Chen, Stéphane Larochelle, Xiaoming Li and Beat Suter

doi:10.1038/nature01746

First paragraph | Full Text | PDF (405K) | Supplementary information

Naturejobs

Science rocks p233

Paul Smaglik

doi:10.1038/nj6945-233a

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The learning curve p234

Students starting their PhD and postdocs moving into fresh areas of research often find themselves in need of different technical skills. How does everyone get up to speed? Karen Kreeger reports.

Karen Kreeger

doi:10.1038/nj6945-234a

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