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Nature 424, 81-84 (3 July 2003) | doi:10.1038/nature01733; Received 9 February 2003; Accepted 8 May 2003; Published online 18 June 2003

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A TRPV family ion channel required for hearing in Drosophila

Janghwan Kim1,2, Yun Doo Chung3,4, Dae-young Park1, SooKyung Choi1, Dong Wook Shin1, Heun Soh5, Hye Won Lee1, Wonseok Son1, Jeongbin Yim6, Chul-Seung Park5, Maurice J. Kernan3,4 & Changsoo Kim1

  1. Department of Genetics, Hanwha Chemical Co. R&D Center, Sinsung-Dong, Yusung-Gu, Daejeon 305-345, Korea
  2. Department of Microbiology, Chungnam National University, Daejeon 305-764, Korea
  3. Department of Neurobiology & Behavior, State University of New York at Stony Brook, New York 11794, USA
  4. Center for Developmental Genetics, State University of New York at Stony Brook, New York 11794, USA
  5. Department of Life Science, K-JIST, Gwangju 500-712, Korea
  6. National Creative Research Institute for Genetic Reprogramming, Seoul National University, Seoul 151-742, Korea

Correspondence to: Changsoo Kim1 Correspondence and requests for materials should be addressed to C.K. (Email: changgk2001@hanmail.net). The nan sequence is deposited in GenBank under accession number AY262004.

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The many types of insect ear share a common sensory element, the chordotonal organ, in which sound-induced antennal or tympanal vibrations are transmitted to ciliated sensory neurons and transduced to receptor potentials1, 2. However, the molecular identity of the transducing ion channels in chordotonal neurons, or in any auditory system, is still unknown3, 4. Drosophila that are mutant for NOMPC, a transient receptor potential (TRP) superfamily ion channel, lack receptor potentials and currents in tactile bristles5, 6 but retain most of the antennal sound-evoked response7, suggesting that a different channel is the primary transducer in chordotonal organs. Here we describe the Drosophila Nanchung (Nan) protein, an ion channel subunit similar to vanilloid-receptor-related (TRPV) channels of the TRP superfamily. Nan mediates hypo-osmotically activated calcium influx and cation currents in cultured cells. It is expressed in vivo exclusively in chordotonal neurons and is localized to their sensory cilia. Antennal sound-evoked potentials are completely absent in mutants lacking Nan, showing that it is an essential component of the chordotonal mechanotransducer.

  1. Department of Genetics, Hanwha Chemical Co. R&D Center, Sinsung-Dong, Yusung-Gu, Daejeon 305-345, Korea
  2. Department of Microbiology, Chungnam National University, Daejeon 305-764, Korea
  3. Department of Neurobiology & Behavior, State University of New York at Stony Brook, New York 11794, USA
  4. Center for Developmental Genetics, State University of New York at Stony Brook, New York 11794, USA
  5. Department of Life Science, K-JIST, Gwangju 500-712, Korea
  6. National Creative Research Institute for Genetic Reprogramming, Seoul National University, Seoul 151-742, Korea

Correspondence to: Changsoo Kim1 Correspondence and requests for materials should be addressed to C.K. (Email: changgk2001@hanmail.net). The nan sequence is deposited in GenBank under accession number AY262004.