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Nature 423, 818-819 (19 June 2003) | doi:10.1038/423818b
Cell cycle: Degradation ensures integrity
Anatoliy Li & J. Julian Blow
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Abstract
Protein degradation terminates a range of biochemical activities in living cells. New work shows that a component of the 'licensing' system for DNA replication must be degraded to prevent re-replication during cell division.
How would you ensure that a biochemical reaction is irreversible? This is a key problem in living organisms, because many of their control systems must progress unidirectionally through a series of different states.
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