Supplementary information
From the following article:
Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease
Hironori Ueda,
Joanna M. M. Howson,
Laura Esposito,
Joanne Heward,
Snook,
Giselle Chamberlain,
Daniel B. Rainbow,
Kara M. D. Hunter,
Annabel N. Smith,
Gianfranco Di Genova,
Mathias H. Herr,
Ingrid Dahlman,
Felicity Payne,
Deborah Smyth,
Christopher Lowe,
Rebecca C. J. Twells,
Sarah Howlett,
Barry Healy,
Sarah Nutland,
Helen E. Rance,
Vin Everett,
Luc J. Smink,
Alex C. Lam,
Heather J. Cordell,
Neil M. Walker,
Cristina Bordin,
John Hulme,
Costantino Motzo,
Francesco Cucca,
J. Fred Hess,
Michael L. Metzker,
Jane Rogers,
Simon Gregory,
Amit Allahabadia,
Ratnasingam Nithiyananthan,
Eva Tuomilehto-Wolf,
Jaakko Tuomilehto,
Polly Bingley,
Kathleen M. Gillespie,
Dag E. Undlien,
Kjersti S. Rønningen,
Cristian Guja,
Constantin Ionescu-Tîrgovi
te,
David A. Savage,
A. Peter Maxwell,
Dennis J. Carson,
Chris C. Patterson,
Jayne A. Franklyn,
David G. Clayton,
Laurence B. Peterson,
Linda S. Wicker,
John A. Todd
and
Stephen C. L. Gough
Nature 423, 506-511(29 May 2003)
Supplementary Information A: Description for CD28-CTLA4-ICOS region of (a) genomic informatics methods and results, including human-mouse comparative sequence analysis and gene annotation, (b) details of the single nucleotide polymorphisms – their sequences and genotyping QC results and (c) methods and results from the analysis of the transcription of the CTLA-4 gene.
Supplementary Information B: Intermarker linkage disequilibrium analysis for the 108 single nucleotide polymorphisms studied in the CD28-CTLA4-ICOS region and a detailed description of the fine mapping approach using logistic regression analyses in Graves' disease and in type 1 diabetes, including single point and haplotype results.
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