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Nature 423, 493-495 (29 May 2003) |
Open Innovation Challenges
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Protect Enzyme from In Planta Degradation
A proposal for stable expression of an enzyme in corn seed is desired.
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Fast Growth of Transformed Soybean Shoots
A method for accelerating growth of soybean shoots is desired.
- More Challenges
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Director of NMR
- New York Structural Biology Center
- New York, New York
Gastroenterologist
- Florida Gastroenterology Practice
- Florida, USA
Cell division: Genome maintenance
Jordan W. Raff
Abstract
Early fruitfly embryos have an unusual means of halting the division of any nuclei containing damaged DNA. A key component of this mechanism has now been identified, and might have implications for cancer.
Maintaining the integrity of the genome is a crucial task for any cell. Two proteins, called checkpoint kinases 1 (Chk1) and 2 (Chk2), help to achieve this in many species, and mutations in the genes encoding these proteins have been linked to the generation of cancer in humans.
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