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Nature 423, 493-495 (29 May 2003) |
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Cell division: Genome maintenance
Jordan W. Raff
Abstract
Early fruitfly embryos have an unusual means of halting the division of any nuclei containing damaged DNA. A key component of this mechanism has now been identified, and might have implications for cancer.
Maintaining the integrity of the genome is a crucial task for any cell. Two proteins, called checkpoint kinases 1 (Chk1) and 2 (Chk2), help to achieve this in many species, and mutations in the genes encoding these proteins have been linked to the generation of cancer in humans.
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