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From the following article:

Insulin-regulated hepatic gluconeogenesis through FOXO1–PGC-1alpha interaction

Pere Puigserver, James Rhee, Jerry Donovan, Christopher J. Walkey, J. Cliff Yoon, Francesco Oriente, Yukari Kitamura, Jennifer Altomonte, Hengjiang Dong, Domenico Accili and Bruce M. Spiegelman

Nature 423, 550-555(29 May 2003)

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Figure 1 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com

Figure 1

Insulin regulates PGC-1alpha action but not PGC-1alpha gene expression.

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Figure 2

Co-activation of FOXO1 by PGC-1alpha is required for gluconeogenic gene expression.

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Figure 3

Insulin regulation of PGC-1alpha action on gluconeogenesis depends on FOXO1 function in hepatocyte cells.

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Figure 4

Insulin regulation of PGC-1alpha action on gluconeogenic genes depends on FOXO1 function in live mice.

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