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Alzheimer's disease

Mental plaque removal

Lithium, already used to treat psychiatric disorders, has been found to reduce amyloid-peptide production in a mouse model of Alzheimer's disease. The implication is that lithium's target molecule helps to generate the peptides.

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Figure 1: Plaques and tangles in Alzheimer's disease.

References

  1. Phiel, C. J., Wilson, C. A., Lee, V. M.-Y & Klein, P. S. Nature 423, 435–439 (2003).

    Article  ADS  CAS  Google Scholar 

  2. Doble, B. W. & Woodgett, J. R. J. Cell Sci. 116, 1175–1186 (2003).

    Article  CAS  Google Scholar 

  3. Lucas, J. J. et al. EMBO J. 20, 27–39 (2001).

    Article  CAS  Google Scholar 

  4. Spittaels, K. et al. J. Biol. Chem. 275, 41340–41349 (2000).

    Article  CAS  Google Scholar 

  5. Annaert, W. & De Strooper, B. Annu. Rev. Cell. Dev. Biol. 18, 25–51 (2002).

    Article  CAS  Google Scholar 

  6. Hardy, J. & Selkoe, D. J. Science 297, 353–356 (2002).

    Article  ADS  CAS  Google Scholar 

  7. Dominguez, D. I. & De Strooper, B. Trends Pharmacol. Sci. 23, 324–330 (2002).

    Article  CAS  Google Scholar 

  8. Sun, X. et al. Neurosci. Lett. 321, 61–64 (2002).

    Article  CAS  Google Scholar 

  9. De Strooper, B. et al. Nature 391, 387–390 (1998).

    Article  ADS  CAS  Google Scholar 

  10. De Strooper, B. Neuron 38, 9–12 (2003).

    Article  CAS  Google Scholar 

  11. Takashima, A. et al. Proc. Natl Acad. Sci. USA 95, 9637–9641 (1998).

    Article  ADS  CAS  Google Scholar 

  12. Kang, D. et al. Cell 110, 751–762 (2002).

    Article  CAS  Google Scholar 

  13. Kirschenbaum, F., Hsu, S. C., Cordell, B. & McCarthy, J. V. J. Biol. Chem. 276, 7366–7375 (2001).

    Article  CAS  Google Scholar 

  14. Hoeflich, K. P. et al. Nature 406, 86–90 (2000).

    Article  ADS  CAS  Google Scholar 

  15. De Strooper, B. et al. Nature 398, 518–522 (1999).

    Article  ADS  CAS  Google Scholar 

Download references

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Correspondence to Bart De Strooper or James Woodgett.

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De Strooper, B., Woodgett, J. Mental plaque removal. Nature 423, 392–393 (2003). https://doi.org/10.1038/423392a

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