Access
To read this story in full you will need to login or make a payment (see right).
News and Views
Nature 423, 392-393 (22 May 2003) | doi:10.1038/423392a
Open Innovation Challenges
-
Novel Approaches to Protecting Maize from Insect Damage
The Seeker is looking for novel approaches to protecting maize from insect damage. This Challenge re...
-
Methods of Modeling Adaptation in Populations
The analysis of adaptation with a population is a frequently encountered computational modeling scen...
- More Challenges
- Powered by:
nature jobs
Senior Staff Scientist
- National Institute of Mental Health (NIMH)
- Bethesda, Maryland
Assistant / Associate / Full Professor
- Northeastern University
- Boston, MA
Alzheimer's disease: Mental plaque removal
Bart De Strooper & James Woodgett
Abstract
Lithium, already used to treat psychiatric disorders, has been found to reduce amyloid-peptide production in a mouse model of Alzheimer's disease. The implication is that lithium's target molecule helps to generate the peptides.
Studies of people with Alzheimer's disease have revealed several notable changes in the brain, including the build-up of protein deposits known as amyloid plaques outside nerve cells, and the accumulation of so-called neurofibrillary tangles inside the cells. Should treatments for this disease target the plaques or the tangles?
To read this story in full you will need to login or make a payment (see right).
