Table of contents


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Editorials

Don't mention the war... p207

The United States could taint the ITER project to build a prototype magnetic-confinement fusion reactor if it exploits the selection of a site to settle diplomatic scores. But its European partners don't need to let that happen.

doi:10.1038/423207a


Gene patents and the public good p207

A race to claim patents on the SARS virus raises questions about the patent system's ability to cope with genomics.

doi:10.1038/423207b


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News

Biologists take tentative steps towards bespoke cancer drugs p209

David Cyranoski


Researchers rue hasty destruction of wheat p210

Carina Dennis


Cash crisis casts pall over synchrotron X-ray source p210

Carina Dennis

doi:10.1038/423210b


US support for Spain triggers unease over fusion project p211

Geoff Brumfiel and Declan Butler

doi:10.1038/423211a


Medical council pins hopes on public advocate of science p211

Jim Giles

doi:10.1038/423211b


Europe dithers as Canada cuts cod fishing p212

Quirin Schiermeier

doi:10.1038/423212a


Asteroid probe to test technologies p212

David Cyranoski

doi:10.1038/423212b


Low embryo count fuels US stem-cell debate p213

Kendall Powell

doi:10.1038/423213a


MIT pulls out of Asian Media Lab in argument over role p213

K. S. Jayaraman

doi:10.1038/423213b


News in brief p214

doi:10.1038/423214a


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News feature

The man they love to hate p216

Bjørn Lomborg is reviled by green activists and has come under ferocious attack from many environmental scientists. Just why does he provoke such strong reactions, and how influential might his opinions become? Jim Giles investigates.

Jim Giles

doi:10.1038/423216a


Conservation biology: Mock turtles p219

One reptile enthusiast, working with a handful of academics, has described a clutch of new Asian turtle species since the late 1980s. But are they what they seem? Rex Dalton reports on a herpetological débâcle.

Rex Dalton

doi:10.1038/423219a


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Correspondence

Japanese system buries the individual researcher p221

The hierarchy ensures that young scientists' grants are absorbed into the lab's budget.

Ippeita Dan

doi:10.1038/423221a


Early work on elephant gait not to be forgotten p221

Oliver Sacks

doi:10.1038/423221b


Making a song and dance about emotion p221

Rupert C. Marshall

doi:10.1038/423221c


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Book Reviews

The X and Y of sex p223

The sex chromosomes, especially the degenerate Y, have a lot to answer for.

Jennifer A. Marshall Graves reviews The X in Sex: How the Chromosome Controls our Lives by David Bainbridge and Y: The Descent of Men by Steve Jones

doi:10.1038/423223a


The Harvard blood group p224

Charles Tanford and Jacqueline Reynolds review Edwin J. Cohn and the Development of Protein Chemistry: With a Detailed Account of His Work on the Fractionation of Blood During and After World War II by Douglas M. Surgenor

doi:10.1038/423224a


Heading for safer shores? p225

N. Mrosovsky reviews The Biology of Sea Turtles, Volume II

doi:10.1038/423225a


Balancing planets and molecules p225

David W. Schindler reviews Ecological Stoichiometry: The Biology of Elements from Molecules to the Biosphere by Robert W. Sterner and James J. Elser

doi:10.1038/423225b


Science in culture p226

Alison Abbott reviews

doi:10.1038/423226a


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Concepts

Mental self: The person within p227

Antonio Damasio

doi:10.1038/423227a


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News and Views

Plant reproduction: Sex and self-denial p229

Many plants are self-incompatible — that is, they have mechanisms to prevent fertilization by their own pollen. A familiar and uncommonly versatile protein, ubiquitin, is found to be a central player in one such system.

Ed Newbigin and Richard D. Vierstra

doi:10.1038/423229a


Cosmology: A just-so story p230

Physicists are learning to live with Einstein's 'fudge factor', the cosmological constant. New thinking attempts to tie its value to other fundamental constants in elementary particle physics.

Lawrence M. Krauss

doi:10.1038/423230a


Stem cells: Self-renewal writ in blood p231

The ability to self-renew is a defining property of stem cells, and a protein in blood stem cells that controls their self-renewal has been discovered. That same protein is also crucial for the development of leukaemia.

John E. Dick

doi:10.1038/423231a


100 and 50 years ago p232

doi:10.1038/423232a


Genomics: Yeast rises again p233

What's in a genome? The short answer is that you can't really say in detail for any one species until you have the genome sequences of a variety of other species — some closely related, others less so — to compare it with.

Steven L. Salzberg

doi:10.1038/423233a


Molecular biology: Disruptive influence p234

Recombination is a vital cellular process implicated in DNA metabolism — but it must be tightly controlled. The discovery of a protein that disrupts recombination intermediates sheds light on the control mechanisms.

Marco Foiani

doi:10.1038/423234a


Planetary science: Jupiter's moonopoly p235

A further 23 satellites have been discovered in orbit around Jupiter. With diameters of between two and eight kilometres, the moons are the smallest yet spotted around any planet.

Douglas P. Hamilton

doi:10.1038/423235a


Corrections p236

doi:10.1038/423236a


Obituary: Charles A. Janeway Jr (1943–2003) p237

William E. Paul and Ronald N. Germain

doi:10.1038/423237a


news and views in brief p238

doi:10.1038/423238a


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Brief Communications

Planetary science: Mission to Earth's core — a modest proposal p239

Not science fiction, but a technically feasible plan to probe our planet's inner workings.

David J. Stevenson

doi:10.1038/423239a


Aetiology: Koch's postulates fulfilled for SARS virus p240

Ron A. M. Fouchier, Thijs Kuiken, Martin Schutten, Geert van Amerongen, Gerard J. J. van Doornum, Bernadette G. van den Hoogen, Malik Peiris, Wilina Lim, Klaus Stöhr and Albert D. M. E. Osterhaus

doi:10.1038/423240a


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Articles

Sequencing and comparison of yeast species to identify genes and regulatory elements p241

Manolis Kellis, Nick Patterson, Matthew Endrizzi, Bruce Birren and Eric S. Lander

doi:10.1038/nature01644

See also: News and Views by Salzberg


Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells p255

Julie Lessard and Guy Sauvageau

doi:10.1038/nature01572

See also: News and Views by Dick


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Letters to Nature

An abundant population of small irregular satellites around Jupiter p261

Scott S. Sheppard and David C. Jewitt

doi:10.1038/nature01584

See also: News and Views by Hamilton


Chaos-assisted capture of irregular moons p264

Sergey A. Astakhov, Andrew D. Burbanks, Stephen Wiggins and David Farrelly

doi:10.1038/nature01622


A theory of power-law distributions in financial market fluctuations p267

Xavier Gabaix, Parameswaran Gopikrishnan, Vasiliki Plerou and H. Eugene Stanley

doi:10.1038/nature01624


Measurement of the displacement field of dislocations to 0.03 Å by electron microscopy p270

Martin J. Hÿtch, Jean-Luc Putaux and Jean-Michel Pénisson

doi:10.1038/nature01638


Detection of bromine monoxide in a volcanic plume p273

N. Bobrowski, G. Hönninger, B. Galle and U. Platt

doi:10.1038/nature01625


Parallel extinction risk and global distribution of languages and species p276

William J. Sutherland

doi:10.1038/nature01607


Rapid worldwide depletion of predatory fish communities p280

Ransom A. Myers and Boris Worm

doi:10.1038/nature01610


Attractor dynamics of network UP states in the neocortex p283

Rosa Cossart, Dmitriy Aronov and Rafael Yuste

doi:10.1038/nature01614


Turning on and off recurrent balanced cortical activity p288

Yousheng Shu, Andrea Hasenstaub and David A. McCormick

doi:10.1038/nature01616


Recurrent de novo point mutations in lamin A cause Hutchinson–Gilford progeria syndrome p293

Maria Eriksson, W. Ted Brown, Leslie B. Gordon, Michael W. Glynn, Joel Singer, Laura Scott, Michael R. Erdos, Christiane M. Robbins, Tracy Y. Moses, Peter Berglund, Amalia Dutra, Evgenia Pak, Sandra Durkin, Antonei B. Csoka, Michael Boehnke, Thomas W. Glover and Francis S. Collins

doi:10.1038/nature01629


A progeroid syndrome in mice is caused by defects in A-type lamins p298

Leslie C. Mounkes, Serguei Kozlov, Lidia Hernandez, Teresa Sullivan and Colin L. Stewart

doi:10.1038/nature01631


Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells p302

In-kyung Park, Dalong Qian, Mark Kiel, Michael W. Becker, Michael Pihalja, Irving L. Weissman, Sean J. Morrison and Michael F. Clarke

doi:10.1038/nature01587

See also: News and Views by Dick


DNA helicase Srs2 disrupts the Rad51 presynaptic filament p305

Lumir Krejci, Stephen Van Komen, Ying Li, Jana Villemain, Mothe Sreedhar Reddy, Hannah Klein, Thomas Ellenberger and Patrick Sung

doi:10.1038/nature01577

See also: News and Views by Foiani


The Srs2 helicase prevents recombination by disrupting Rad51 nucleoprotein filaments p309

Xavier Veaute, Josette Jeusset, Christine Soustelle, Stephen C. Kowalczykowski, Eric Le Cam and Francis Fabre

doi:10.1038/nature01585

See also: News and Views by Foiani


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New on the Market

Chromatography developments p313

Acronyms abound in two pages devoted to GC, TLC, GPC, HPLC etc.

doi:10.1038/423313a


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Insight

introduction

bone and cartilage p315

Natalie DeWitt

doi:10.1038/423315a


Overview

The complexities of skeletal biology p316

Gerard Karsenty

doi:10.1038/nature01654


Review article

Deciphering skeletal patterning: clues from the limb p319

Francesca V. Mariani and Gail R. Martin

doi:10.1038/nature01655


Cranial skeletal biology p326

J. A. Helms and R. A. Schneider

doi:10.1038/nature01656


Developmental regulation of the growth plate p332

Henry M. Kronenberg

doi:10.1038/nature01657


Osteoclast differentiation and activation p337

William J. Boyle, W. Scott Simonet and David L. Lacey

doi:10.1038/nature01658


The genetic basis for skeletal diseases p343

Elazar Zelzer and Bjorn R. Olsen

doi:10.1038/nature01659


Control of osteoblast function and regulation of bone mass p349

Shun-ichi Harada and Gideon A. Rodan

doi:10.1038/nature01660


Evolving concepts of rheumatoid arthritis p356

Gary S. Firestein

doi:10.1038/nature01661


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Naturejobs

Prospects

Biotech's balancing act p363

Paul Smaglik

doi:10.1038/nj6937-363a


Regions

Heidelberg: Language lessons p364

Paul Smaglik

doi:10.1038/nj6937-364a


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